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A Combination of a GnRH Antagonist and Agonist for Fertility Preservation in an Adolescent Female Murine Model
Recent studies have suggested that GnRH agonists (GnRHags) protect ovarian function following chemotherapy. Here, we study the effect of a combination of GnRH antagonist (GnRHan) and GnRHag for gonadal protection from gonadotoxic chemotherapy in adolescent female rats. Cycling Sprague Dawley rats we...
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| Published in: | Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2017-09, Vol.24 (9), p.1280-1283 |
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| container_end_page | 1283 |
| container_issue | 9 |
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| container_title | Reproductive sciences (Thousand Oaks, Calif.) |
| container_volume | 24 |
| creator | Knudtson, Jennifer Flora Tellez Santos, Marlen Failor, Courtney M. Binkley, Peter A. Venesky, Jacob P. Tekmal, Rajeshwar R. Robinson, Randal D. Schenken, Robert S. |
| description | Recent studies have suggested that GnRH agonists (GnRHags) protect ovarian function following chemotherapy. Here, we study the effect of a combination of GnRH antagonist (GnRHan) and GnRHag for gonadal protection from gonadotoxic chemotherapy in adolescent female rats. Cycling Sprague Dawley rats were treated at adolescent age. Thirty female rats were randomized to 5 treatment groups (n = 6/group): (1) placebo, (2) cyclophosphamide (CPA) alone, (3) GnRHan followed by GnRHag with placebo, (4) GnRHan followed by GnRHag with CPA, and (5) GnRHag with CPA. The main outcome measure was live birth rate (LBR), and secondary measures included rat weight, ovarian volume, and follicles. Group 2 had decreased LBR compared to all other groups. Group 4 and 5 had LBR similar to placebo. There was no difference in the ovarian volume. The CPA-alone group had decreased number of antral follicles compared to control. These studies demonstrate that the combination of GnRHan and GnRHag and GnRHag alone preserved fertility in female adolescent rats following gonadotoxic chemotherapy treatment. The addition of a GnRHan to a GnRHag does not confer a greater protective effect. |
| doi_str_mv | 10.1177/1933719116682876 |
| format | article |
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Here, we study the effect of a combination of GnRH antagonist (GnRHan) and GnRHag for gonadal protection from gonadotoxic chemotherapy in adolescent female rats. Cycling Sprague Dawley rats were treated at adolescent age. Thirty female rats were randomized to 5 treatment groups (n = 6/group): (1) placebo, (2) cyclophosphamide (CPA) alone, (3) GnRHan followed by GnRHag with placebo, (4) GnRHan followed by GnRHag with CPA, and (5) GnRHag with CPA. The main outcome measure was live birth rate (LBR), and secondary measures included rat weight, ovarian volume, and follicles. Group 2 had decreased LBR compared to all other groups. Group 4 and 5 had LBR similar to placebo. There was no difference in the ovarian volume. The CPA-alone group had decreased number of antral follicles compared to control. These studies demonstrate that the combination of GnRHan and GnRHag and GnRHag alone preserved fertility in female adolescent rats following gonadotoxic chemotherapy treatment. The addition of a GnRHan to a GnRHag does not confer a greater protective effect.</description><identifier>ISSN: 1933-7191</identifier><identifier>EISSN: 1933-7205</identifier><identifier>DOI: 10.1177/1933719116682876</identifier><identifier>PMID: 28290768</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject><![CDATA[Animals ; Antineoplastic Agents, Alkylating - administration & dosage ; Cyclophosphamide - administration & dosage ; Embryology ; Female ; Fertility Agents, Female - administration & dosage ; Fertility Preservation - methods ; Gonadotropin-Releasing Hormone - administration & dosage ; Gonadotropin-Releasing Hormone - analogs & derivatives ; Hormone Antagonists - administration & dosage ; Leuprolide - administration & dosage ; Medicine & Public Health ; Models, Animal ; Obstetrics/Perinatology/Midwifery ; Original ; Original Article ; Ovary - drug effects ; Rats ; Rats, Sprague-Dawley ; Reproductive Medicine]]></subject><ispartof>Reproductive sciences (Thousand Oaks, Calif.), 2017-09, Vol.24 (9), p.1280-1283</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016 2016 Society for Gynecologic Investigation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-6a0cbc486be29ca68edfcca56937a91c3950489ca1c20d915b9f6911f8becf7a3</citedby><cites>FETCH-LOGICAL-c476t-6a0cbc486be29ca68edfcca56937a91c3950489ca1c20d915b9f6911f8becf7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28290768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knudtson, Jennifer Flora</creatorcontrib><creatorcontrib>Tellez Santos, Marlen</creatorcontrib><creatorcontrib>Failor, Courtney M.</creatorcontrib><creatorcontrib>Binkley, Peter A.</creatorcontrib><creatorcontrib>Venesky, Jacob P.</creatorcontrib><creatorcontrib>Tekmal, Rajeshwar R.</creatorcontrib><creatorcontrib>Robinson, Randal D.</creatorcontrib><creatorcontrib>Schenken, Robert S.</creatorcontrib><title>A Combination of a GnRH Antagonist and Agonist for Fertility Preservation in an Adolescent Female Murine Model</title><title>Reproductive sciences (Thousand Oaks, Calif.)</title><addtitle>Reprod. Sci</addtitle><addtitle>Reprod Sci</addtitle><description>Recent studies have suggested that GnRH agonists (GnRHags) protect ovarian function following chemotherapy. Here, we study the effect of a combination of GnRH antagonist (GnRHan) and GnRHag for gonadal protection from gonadotoxic chemotherapy in adolescent female rats. Cycling Sprague Dawley rats were treated at adolescent age. Thirty female rats were randomized to 5 treatment groups (n = 6/group): (1) placebo, (2) cyclophosphamide (CPA) alone, (3) GnRHan followed by GnRHag with placebo, (4) GnRHan followed by GnRHag with CPA, and (5) GnRHag with CPA. The main outcome measure was live birth rate (LBR), and secondary measures included rat weight, ovarian volume, and follicles. Group 2 had decreased LBR compared to all other groups. Group 4 and 5 had LBR similar to placebo. There was no difference in the ovarian volume. The CPA-alone group had decreased number of antral follicles compared to control. These studies demonstrate that the combination of GnRHan and GnRHag and GnRHag alone preserved fertility in female adolescent rats following gonadotoxic chemotherapy treatment. The addition of a GnRHan to a GnRHag does not confer a greater protective effect.</description><subject>Animals</subject><subject>Antineoplastic Agents, Alkylating - administration & dosage</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>Embryology</subject><subject>Female</subject><subject>Fertility Agents, Female - administration & dosage</subject><subject>Fertility Preservation - methods</subject><subject>Gonadotropin-Releasing Hormone - administration & dosage</subject><subject>Gonadotropin-Releasing Hormone - analogs & derivatives</subject><subject>Hormone Antagonists - administration & dosage</subject><subject>Leuprolide - administration & dosage</subject><subject>Medicine & Public Health</subject><subject>Models, Animal</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Original</subject><subject>Original Article</subject><subject>Ovary - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reproductive Medicine</subject><issn>1933-7191</issn><issn>1933-7205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkUtLxTAQhYMovveuJEs31aS9zWMjlIsvUBTRdUjT6TXSJpq0gv_eXO4DdSGuMuR852Qyg9ARJaeUcn5GZVFwKillTOSCsw20O7_KeE7KzVWd9B20F-MrIeVE5mIb7eQil4QzsYtchae-r63Tg_UO-xZrfOUer3HlBj3zzsYBa9fgalm3PuBLCIPt7PCJHwJECB8Lr3WJxFXjO4gG3JC4XneA78ZgXTp8A90B2mp1F-Fwee6j58uLp-l1dnt_dTOtbjMz4WzImCamNhPBasil0UxA0xqjSyYLriU1hSzJRCSFmpw0kpa1bFkaQytqMC3XxT46X-S-jXUPzbydoDv1Fmyvw6fy2qqfirMvauY_VJlGRgRNASfLgODfR4iD6m36VddpB36MigrOy5wzViaULFATfIwB2vUzlKj5mtTvNSXL8ff21obVXhJAF0BMkptBUK9-DC6N7K_QbOnRM_gH_wU6RasZ</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Knudtson, Jennifer Flora</creator><creator>Tellez Santos, Marlen</creator><creator>Failor, Courtney M.</creator><creator>Binkley, Peter A.</creator><creator>Venesky, Jacob P.</creator><creator>Tekmal, Rajeshwar R.</creator><creator>Robinson, Randal D.</creator><creator>Schenken, Robert S.</creator><general>SAGE Publications</general><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170901</creationdate><title>A Combination of a GnRH Antagonist and Agonist for Fertility Preservation in an Adolescent Female Murine Model</title><author>Knudtson, Jennifer Flora ; Tellez Santos, Marlen ; Failor, Courtney M. ; Binkley, Peter A. ; Venesky, Jacob P. ; Tekmal, Rajeshwar R. ; Robinson, Randal D. ; Schenken, Robert S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-6a0cbc486be29ca68edfcca56937a91c3950489ca1c20d915b9f6911f8becf7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Alkylating - administration & dosage</topic><topic>Cyclophosphamide - administration & dosage</topic><topic>Embryology</topic><topic>Female</topic><topic>Fertility Agents, Female - administration & dosage</topic><topic>Fertility Preservation - methods</topic><topic>Gonadotropin-Releasing Hormone - administration & dosage</topic><topic>Gonadotropin-Releasing Hormone - analogs & derivatives</topic><topic>Hormone Antagonists - administration & dosage</topic><topic>Leuprolide - administration & dosage</topic><topic>Medicine & Public Health</topic><topic>Models, Animal</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Original</topic><topic>Original Article</topic><topic>Ovary - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reproductive Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knudtson, Jennifer Flora</creatorcontrib><creatorcontrib>Tellez Santos, Marlen</creatorcontrib><creatorcontrib>Failor, Courtney M.</creatorcontrib><creatorcontrib>Binkley, Peter A.</creatorcontrib><creatorcontrib>Venesky, Jacob P.</creatorcontrib><creatorcontrib>Tekmal, Rajeshwar R.</creatorcontrib><creatorcontrib>Robinson, Randal D.</creatorcontrib><creatorcontrib>Schenken, Robert S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knudtson, Jennifer Flora</au><au>Tellez Santos, Marlen</au><au>Failor, Courtney M.</au><au>Binkley, Peter A.</au><au>Venesky, Jacob P.</au><au>Tekmal, Rajeshwar R.</au><au>Robinson, Randal D.</au><au>Schenken, Robert S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Combination of a GnRH Antagonist and Agonist for Fertility Preservation in an Adolescent Female Murine Model</atitle><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle><stitle>Reprod. Sci</stitle><addtitle>Reprod Sci</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>24</volume><issue>9</issue><spage>1280</spage><epage>1283</epage><pages>1280-1283</pages><issn>1933-7191</issn><eissn>1933-7205</eissn><abstract>Recent studies have suggested that GnRH agonists (GnRHags) protect ovarian function following chemotherapy. Here, we study the effect of a combination of GnRH antagonist (GnRHan) and GnRHag for gonadal protection from gonadotoxic chemotherapy in adolescent female rats. Cycling Sprague Dawley rats were treated at adolescent age. Thirty female rats were randomized to 5 treatment groups (n = 6/group): (1) placebo, (2) cyclophosphamide (CPA) alone, (3) GnRHan followed by GnRHag with placebo, (4) GnRHan followed by GnRHag with CPA, and (5) GnRHag with CPA. The main outcome measure was live birth rate (LBR), and secondary measures included rat weight, ovarian volume, and follicles. Group 2 had decreased LBR compared to all other groups. Group 4 and 5 had LBR similar to placebo. There was no difference in the ovarian volume. The CPA-alone group had decreased number of antral follicles compared to control. These studies demonstrate that the combination of GnRHan and GnRHag and GnRHag alone preserved fertility in female adolescent rats following gonadotoxic chemotherapy treatment. The addition of a GnRHan to a GnRHag does not confer a greater protective effect.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>28290768</pmid><doi>10.1177/1933719116682876</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Reproductive sciences (Thousand Oaks, Calif.), 2017-09, Vol.24 (9), p.1280-1283 |
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| subjects | Animals Antineoplastic Agents, Alkylating - administration & dosage Cyclophosphamide - administration & dosage Embryology Female Fertility Agents, Female - administration & dosage Fertility Preservation - methods Gonadotropin-Releasing Hormone - administration & dosage Gonadotropin-Releasing Hormone - analogs & derivatives Hormone Antagonists - administration & dosage Leuprolide - administration & dosage Medicine & Public Health Models, Animal Obstetrics/Perinatology/Midwifery Original Original Article Ovary - drug effects Rats Rats, Sprague-Dawley Reproductive Medicine |
| title | A Combination of a GnRH Antagonist and Agonist for Fertility Preservation in an Adolescent Female Murine Model |
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