Baseline TNFα Operational Capacity in Fetal and Maternal Circulation Prior to the Onset of Labor: Tuned for Different Purposes

Objective: In this study, we sought to characterize the tumor necrosis factor α (TNFα) baseline operational capacity in mature fetuses and their mothers prior to the onset of labor. Materials and Methods: We used an experimental pregnant nonhuman primate model to measure the plasma concentration of...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2013-07, Vol.20 (7), p.838-844
Main Authors: Santolaya, Jacobo L., Kugler, Lindsay, Francois, Lissa, Stefano, Valeria Di, Ebert, Gary A., Wolf, Roman, Wang, Bingbing, Santolaya-Forgas, Joaquín
Format: Article
Language:English
Subjects:
Animals
Biomarkers - blood
Embryology
Female
Labor Onset - blood
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Original
Original Article
Papio
Placental Circulation - physiology
Pregnancy
Reproductive Medicine
Time Factors
Tumor Necrosis Factor-alpha - blood
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Summary:Objective: In this study, we sought to characterize the tumor necrosis factor α (TNFα) baseline operational capacity in mature fetuses and their mothers prior to the onset of labor. Materials and Methods: We used an experimental pregnant nonhuman primate model to measure the plasma concentration of TNFα, TNF transmembrane receptor I (TNFRI), and TNFRII with validated enzyme-linked immunosorbent assays. Coefficients of correlations between the maternal and the fetal values and the soluble TNFα, TNFRI, or TNFRII concentrations and ratios were calculated. Results: The TNFα/TNFRI ratio was 3 times lower in fetal circulation than in maternal circulation. No correlations were noted between the maternal and the fetal TNFα, TNFRI, or TNFRII plasma concentrations. Conclusions: These findings suggest that the fetal and maternal baseline circulatory operational capacities of TNFα are independent of each other and tuned differently. This differential regulation of TNFα in fetal and maternal circulation at the end of pregnancy may be guided to protect the fetus from the systemic inflammatory response that is essential for the mechanisms of labor to proceed in the mother.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719112468953