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Current status of achieving blood pressure target and its clinical correlates in Japanese type 2 diabetes (JDDM45)
Aims/Introduction To investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drug classes as of 2013, and to explore the clinical correlates with achievement of target blood pressure in a large‐scale cohort of Japanese individuals with type...
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| Published in: | Journal of diabetes investigation 2018-05, Vol.9 (3), p.594-601 |
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| container_title | Journal of diabetes investigation |
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| creator | Yokoyama, Hiroki Araki, Shin‐ichi Kawai, Koichi Hirao, Koichi Kurihara, Yoshio Seino, Hiroaki Takamura, Hiroshi Sugimoto, Hidekatsu Okada, Akira Maegawa, Hiroshi |
| description | Aims/Introduction
To investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drug classes as of 2013, and to explore the clinical correlates with achievement of target blood pressure in a large‐scale cohort of Japanese individuals with type 2 diabetes.
Materials and Methods
A nationwide survey was carried out including 12,811 individuals with type 2 diabetes. Participants were divided by achieved blood pressure, |
| doi_str_mv | 10.1111/jdi.12714 |
| format | article |
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To investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drug classes as of 2013, and to explore the clinical correlates with achievement of target blood pressure in a large‐scale cohort of Japanese individuals with type 2 diabetes.
Materials and Methods
A nationwide survey was carried out including 12,811 individuals with type 2 diabetes. Participants were divided by achieved blood pressure, <130/80 or 140/90 mmHg, and the number of drug classes taken.
Results
The percentages achieving a blood pressure of <130/80 or 140/90 mmHg were 52.0% and 86.1%, respectively. The prevalence of hypertension, if defined as ≥130/80 mmHg or treated, became 67.9%. Among participants taking antihypertensive drugs, a blood pressure of <130/80 or <140/90 mmHg was 46.7% and 83.2%, respectively. The percentages of <130/80 mmHg were 55.9% without drugs, 47.1% on one drug, 42.5% on two drugs, 47.2% on three drugs and 56.8% on four or more drugs, respectively. The most prescribed drugs were renin–angiotensin system inhibitors, followed by calcium channel blockers, diuretics and beta‐blockers. The multiple logistic regression analysis showed that a blood pressure <130/80 mmHg was associated with lower values in age, body mass index, albuminuria and glomerular filtration rate, higher proportions on targets for glycosylated hemoglobin A1c and lipids, and less retinopathy.
Conclusions
In type 2 diabetes, hypertension is common, and just 52% achieved <130/80 mmHg, indicating a difficulty in blood pressure lowering. This was correlated with difficulties in glycemic and lipid management, obesity, and vascular complications, implying this clustering to be a serious problem.
A nationwide large‐scale survey was performed to investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drugs. The percentages achieving a blood pressure of <130/80 or 140/90 mmHg were 52.0% and 86.1%, respectively. A difficulty in blood pressure lowering was correlated with difficulties in glycemic and lipid management, obesity, and vascular complications, implying these clustering to be a serious problem.]]></description><identifier>ISSN: 2040-1116</identifier><identifier>EISSN: 2040-1124</identifier><identifier>DOI: 10.1111/jdi.12714</identifier><identifier>PMID: 28731289</identifier><language>eng</language><publisher>Japan: John Wiley & Sons, Inc</publisher><subject>Angiotensin ; Antihypertensive drugs ; Antihypertensives ; Blood pressure ; Blood pressure control ; Body mass index ; Calcium ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diuretics ; Drugs ; Glomerular filtration rate ; Hemoglobin ; Hypertension ; Lipids ; Original ; Renin ; Retinopathy ; Type 2 diabetes</subject><ispartof>Journal of diabetes investigation, 2018-05, Vol.9 (3), p.594-601</ispartof><rights>2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5614-bca8b7eefc0acd80af5cae2301745ac3f6e4273661f06cea2008970dd2304eb83</citedby><cites>FETCH-LOGICAL-c5614-bca8b7eefc0acd80af5cae2301745ac3f6e4273661f06cea2008970dd2304eb83</cites><orcidid>0000-0003-1602-4050</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2034062620/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2034062620?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,11542,25732,27903,27904,36991,36992,44569,46030,46454,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28731289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokoyama, Hiroki</creatorcontrib><creatorcontrib>Araki, Shin‐ichi</creatorcontrib><creatorcontrib>Kawai, Koichi</creatorcontrib><creatorcontrib>Hirao, Koichi</creatorcontrib><creatorcontrib>Kurihara, Yoshio</creatorcontrib><creatorcontrib>Seino, Hiroaki</creatorcontrib><creatorcontrib>Takamura, Hiroshi</creatorcontrib><creatorcontrib>Sugimoto, Hidekatsu</creatorcontrib><creatorcontrib>Okada, Akira</creatorcontrib><creatorcontrib>Maegawa, Hiroshi</creatorcontrib><creatorcontrib>JDDM study group</creatorcontrib><creatorcontrib>the Japan Diabetes Clinical Data Management study group</creatorcontrib><title>Current status of achieving blood pressure target and its clinical correlates in Japanese type 2 diabetes (JDDM45)</title><title>Journal of diabetes investigation</title><addtitle>J Diabetes Investig</addtitle><description><![CDATA[Aims/Introduction
To investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drug classes as of 2013, and to explore the clinical correlates with achievement of target blood pressure in a large‐scale cohort of Japanese individuals with type 2 diabetes.
Materials and Methods
A nationwide survey was carried out including 12,811 individuals with type 2 diabetes. Participants were divided by achieved blood pressure, <130/80 or 140/90 mmHg, and the number of drug classes taken.
Results
The percentages achieving a blood pressure of <130/80 or 140/90 mmHg were 52.0% and 86.1%, respectively. The prevalence of hypertension, if defined as ≥130/80 mmHg or treated, became 67.9%. Among participants taking antihypertensive drugs, a blood pressure of <130/80 or <140/90 mmHg was 46.7% and 83.2%, respectively. The percentages of <130/80 mmHg were 55.9% without drugs, 47.1% on one drug, 42.5% on two drugs, 47.2% on three drugs and 56.8% on four or more drugs, respectively. The most prescribed drugs were renin–angiotensin system inhibitors, followed by calcium channel blockers, diuretics and beta‐blockers. The multiple logistic regression analysis showed that a blood pressure <130/80 mmHg was associated with lower values in age, body mass index, albuminuria and glomerular filtration rate, higher proportions on targets for glycosylated hemoglobin A1c and lipids, and less retinopathy.
Conclusions
In type 2 diabetes, hypertension is common, and just 52% achieved <130/80 mmHg, indicating a difficulty in blood pressure lowering. This was correlated with difficulties in glycemic and lipid management, obesity, and vascular complications, implying this clustering to be a serious problem.
A nationwide large‐scale survey was performed to investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drugs. The percentages achieving a blood pressure of <130/80 or 140/90 mmHg were 52.0% and 86.1%, respectively. A difficulty in blood pressure lowering was correlated with difficulties in glycemic and lipid management, obesity, and vascular complications, implying these clustering to be a serious problem.]]></description><subject>Angiotensin</subject><subject>Antihypertensive drugs</subject><subject>Antihypertensives</subject><subject>Blood pressure</subject><subject>Blood pressure control</subject><subject>Body mass index</subject><subject>Calcium</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diuretics</subject><subject>Drugs</subject><subject>Glomerular filtration rate</subject><subject>Hemoglobin</subject><subject>Hypertension</subject><subject>Lipids</subject><subject>Original</subject><subject>Renin</subject><subject>Retinopathy</subject><subject>Type 2 diabetes</subject><issn>2040-1116</issn><issn>2040-1124</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><recordid>eNp1kcFqGzEQhkVoiEOSQ1-gCHpxDk4krVa7vhSKnTY2Dr20ZzGrnXVk5NVW2k3w20euE9MWMhcJ5uNjfn5CPnJ2w9Pcbmp7w0XB5Qk5F0yyCedCfjj-uRqRqxg3LE1WlkoVZ2QkyiLjopyekzAbQsC2p7GHfojUNxTMo8Un265p5byvaRcwxiEg7SGssafQ1tT2kRpnW2vAUeOTwkGPkdqWLqGDFmPCdx1SQWsLFe534-V8_iDz60ty2oCLePX6XpBf3-5-zu4nqx_fF7Ovq4nJFZeTykBZFYiNYWDqkkGTG0CRMV7IHEzWKJSiyJTiDVMGQTBWTgtW1wmRWJXZBfly8HZDtcXapJQBnO6C3ULYaQ9W_7tp7aNe-yedTzMpcpYE41dB8L8HjL3e2mjQuZTPD1HzqUhYQouEfv4P3fghtCmeFiyTTAkl9sLrA2WCjzFgczyGM70vU6cy9Z8yE_vp7-uP5Ft1Cbg9AM_W4e59k17OFwflC0WPqQ4</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Yokoyama, Hiroki</creator><creator>Araki, Shin‐ichi</creator><creator>Kawai, Koichi</creator><creator>Hirao, Koichi</creator><creator>Kurihara, Yoshio</creator><creator>Seino, Hiroaki</creator><creator>Takamura, Hiroshi</creator><creator>Sugimoto, Hidekatsu</creator><creator>Okada, Akira</creator><creator>Maegawa, Hiroshi</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1602-4050</orcidid></search><sort><creationdate>201805</creationdate><title>Current status of achieving blood pressure target and its clinical correlates in Japanese type 2 diabetes (JDDM45)</title><author>Yokoyama, Hiroki ; Araki, Shin‐ichi ; Kawai, Koichi ; Hirao, Koichi ; Kurihara, Yoshio ; Seino, Hiroaki ; Takamura, Hiroshi ; Sugimoto, Hidekatsu ; Okada, Akira ; Maegawa, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5614-bca8b7eefc0acd80af5cae2301745ac3f6e4273661f06cea2008970dd2304eb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Angiotensin</topic><topic>Antihypertensive drugs</topic><topic>Antihypertensives</topic><topic>Blood pressure</topic><topic>Blood pressure control</topic><topic>Body mass index</topic><topic>Calcium</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diuretics</topic><topic>Drugs</topic><topic>Glomerular filtration rate</topic><topic>Hemoglobin</topic><topic>Hypertension</topic><topic>Lipids</topic><topic>Original</topic><topic>Renin</topic><topic>Retinopathy</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokoyama, Hiroki</creatorcontrib><creatorcontrib>Araki, Shin‐ichi</creatorcontrib><creatorcontrib>Kawai, Koichi</creatorcontrib><creatorcontrib>Hirao, Koichi</creatorcontrib><creatorcontrib>Kurihara, Yoshio</creatorcontrib><creatorcontrib>Seino, Hiroaki</creatorcontrib><creatorcontrib>Takamura, Hiroshi</creatorcontrib><creatorcontrib>Sugimoto, Hidekatsu</creatorcontrib><creatorcontrib>Okada, Akira</creatorcontrib><creatorcontrib>Maegawa, Hiroshi</creatorcontrib><creatorcontrib>JDDM study group</creatorcontrib><creatorcontrib>the Japan Diabetes Clinical Data Management study group</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of diabetes investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokoyama, Hiroki</au><au>Araki, Shin‐ichi</au><au>Kawai, Koichi</au><au>Hirao, Koichi</au><au>Kurihara, Yoshio</au><au>Seino, Hiroaki</au><au>Takamura, Hiroshi</au><au>Sugimoto, Hidekatsu</au><au>Okada, Akira</au><au>Maegawa, Hiroshi</au><aucorp>JDDM study group</aucorp><aucorp>the Japan Diabetes Clinical Data Management study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current status of achieving blood pressure target and its clinical correlates in Japanese type 2 diabetes (JDDM45)</atitle><jtitle>Journal of diabetes investigation</jtitle><addtitle>J Diabetes Investig</addtitle><date>2018-05</date><risdate>2018</risdate><volume>9</volume><issue>3</issue><spage>594</spage><epage>601</epage><pages>594-601</pages><issn>2040-1116</issn><eissn>2040-1124</eissn><abstract><![CDATA[Aims/Introduction
To investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drug classes as of 2013, and to explore the clinical correlates with achievement of target blood pressure in a large‐scale cohort of Japanese individuals with type 2 diabetes.
Materials and Methods
A nationwide survey was carried out including 12,811 individuals with type 2 diabetes. Participants were divided by achieved blood pressure, <130/80 or 140/90 mmHg, and the number of drug classes taken.
Results
The percentages achieving a blood pressure of <130/80 or 140/90 mmHg were 52.0% and 86.1%, respectively. The prevalence of hypertension, if defined as ≥130/80 mmHg or treated, became 67.9%. Among participants taking antihypertensive drugs, a blood pressure of <130/80 or <140/90 mmHg was 46.7% and 83.2%, respectively. The percentages of <130/80 mmHg were 55.9% without drugs, 47.1% on one drug, 42.5% on two drugs, 47.2% on three drugs and 56.8% on four or more drugs, respectively. The most prescribed drugs were renin–angiotensin system inhibitors, followed by calcium channel blockers, diuretics and beta‐blockers. The multiple logistic regression analysis showed that a blood pressure <130/80 mmHg was associated with lower values in age, body mass index, albuminuria and glomerular filtration rate, higher proportions on targets for glycosylated hemoglobin A1c and lipids, and less retinopathy.
Conclusions
In type 2 diabetes, hypertension is common, and just 52% achieved <130/80 mmHg, indicating a difficulty in blood pressure lowering. This was correlated with difficulties in glycemic and lipid management, obesity, and vascular complications, implying this clustering to be a serious problem.
A nationwide large‐scale survey was performed to investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drugs. The percentages achieving a blood pressure of <130/80 or 140/90 mmHg were 52.0% and 86.1%, respectively. A difficulty in blood pressure lowering was correlated with difficulties in glycemic and lipid management, obesity, and vascular complications, implying these clustering to be a serious problem.]]></abstract><cop>Japan</cop><pub>John Wiley & Sons, Inc</pub><pmid>28731289</pmid><doi>10.1111/jdi.12714</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1602-4050</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of diabetes investigation, 2018-05, Vol.9 (3), p.594-601 |
| issn | 2040-1116 2040-1124 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5934250 |
| source | Wiley Online Library Open Access; Publicly Available Content Database; PubMed Central |
| subjects | Angiotensin Antihypertensive drugs Antihypertensives Blood pressure Blood pressure control Body mass index Calcium Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diuretics Drugs Glomerular filtration rate Hemoglobin Hypertension Lipids Original Renin Retinopathy Type 2 diabetes |
| title | Current status of achieving blood pressure target and its clinical correlates in Japanese type 2 diabetes (JDDM45) |
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