Seasonal Incidence of Symptomatic Influenza in the United States

The seasonal incidence of influenza is often approximated as 5%-20%. We used 2 methods to estimate the seasonal incidence of symptomatic influenza in the United States. First, we made a statistical estimate extrapolated from influenza-associated hospitalization rates for 2010-2011 to 2015-2016, coll...

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Bibliographic Details
Published in:Clinical infectious diseases 2018-05, Vol.66 (10), p.1511-1518
Main Authors: Tokars, Jerome I, Olsen, Sonja J, Reed, Carrie
Format: Article
Language:English
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Summary:The seasonal incidence of influenza is often approximated as 5%-20%. We used 2 methods to estimate the seasonal incidence of symptomatic influenza in the United States. First, we made a statistical estimate extrapolated from influenza-associated hospitalization rates for 2010-2011 to 2015-2016, collected as part of national surveillance, covering approximately 9% of the United States, and including the existing mix of vaccinated and unvaccinated persons. Second, we performed a literature search and meta-analysis of published manuscripts that followed cohorts of subjects during 1996-2016 to detect laboratory-confirmed symptomatic influenza among unvaccinated persons; we adjusted this result to the US median vaccination coverage and effectiveness during 2010-2016. The statistical estimate of influenza incidence among all ages ranged from 3.0%-11.3% among seasons, with median values of 8.3% (95% confidence interval [CI], 7.3%-9.7%) for all ages, 9.3% (95% CI, 8.2%-11.1%) for children
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cix1060