Choroid plexus carcinoma with neuronal and glial differentiation in a 7-week-old male Sprague-Dawley rat

We describe a case of choroid plexus carcinoma arising in the cerebrum of a 7-week-old male Sprague-Dawley rat. The tumor mass occupied the right lateral ventricle of the cerebrum. Histological analyses revealed that the epithelial tumor cells had proliferated in tubular, cribriform, papillary and s...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2018, Vol.80(4), pp.611-615
Main Authors: INOHANA, Mari, EGUCHI, Ayumi, NAKAMURA, Misato, NAGAHARA, Rei, WATANABE, Yosuke, YOSHIDA, Toshinori, SHIBUTANI, Makoto
Format: Article
Language:English
Subjects:
Animals
Carcinoma - pathology
Carcinoma - veterinary
Cell Differentiation
Cerebrum
Choroid plexus
Choroid Plexus Neoplasms - pathology
Choroid Plexus Neoplasms - veterinary
Cytokeratin
Doublecortin protein
Growth patterns
Male
Nestin
Neuroglia - pathology
Neuroglia - physiology
Neuronal-glial interactions
Neurons - pathology
Neurons - physiology
OLIG2
Parenchyma
Pathology
Proteins
rat
Rats
Rats, Sprague-Dawley
Rodent Diseases - pathology
Rodents
Tumor cells
Ventricle
Ventricles (cerebral)
Vimentin
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Summary:We describe a case of choroid plexus carcinoma arising in the cerebrum of a 7-week-old male Sprague-Dawley rat. The tumor mass occupied the right lateral ventricle of the cerebrum. Histological analyses revealed that the epithelial tumor cells had proliferated in tubular, cribriform, papillary and solid growth patterns in the vicinity of the choroid plexus, with slight invasion into the cerebrum parenchyma. We divided the tumor cells into cuboidal, elongated and intermediate cells. Immunohistochemical studies showed that these tumor cells expressed relatively high levels of cytokeratin AE1/AE3, vimentin and glial fibrillary acidic proteins, and low levels of nestin, oligodendrocyte transcription factor and doublecortin proteins. The present case was diagnosed as a choroid plexus carcinoma with neuronal and glial differentiation.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.17-0644