Interferon regulatory factor 1 inactivation in human cancer

Interferon regulatory factors (IRFs) are a group of closely related proteins collectively referred to as the IRF family. Members of this family were originally recognized for their roles in inflammatory responses; however, recent research has suggested that they are also involved in tumor biology. T...

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Bibliographic Details
Published in:Bioscience reports 2018-06, Vol.38 (3)
Main Authors: Alsamman, Khaldoon, El-Masry, Omar S
Format: Article
Language:English
Subjects:
Gene Expression Regulation, Neoplastic
Humans
Inflammation - genetics
Inflammation - immunology
Inflammation - therapy
Interferon Regulatory Factor-1 - antagonists & inhibitors
Interferon Regulatory Factor-1 - genetics
Interferon Regulatory Factor-1 - immunology
Interferon Regulatory Factor-2 - antagonists & inhibitors
Interferon Regulatory Factor-2 - genetics
Interferon Regulatory Factor-2 - immunology
Neoplasms - genetics
Neoplasms - immunology
Neoplasms - therapy
Review
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Summary:Interferon regulatory factors (IRFs) are a group of closely related proteins collectively referred to as the IRF family. Members of this family were originally recognized for their roles in inflammatory responses; however, recent research has suggested that they are also involved in tumor biology. This review focusses on current knowledge of the roles of IRF-1 and IRF-2 in human cancer, with particular attention paid to the impact of IRF-1 inactivation. The different mechanisms underlying IRF-1 inactivation and their implications for human cancers and the potential importance of IRF-1 in immunotherapy are also summarized.
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20171672