Trisomy 13‐confined placental mosaicism: is there an increased risk of gestational hypertensive disorders?

What's already known about this topic? Trisomy 13 (T13) pregnancies are associated with increased risk of gestational hypertensive disorders (GHDs). It is unclear if false positive cell‐free DNA results for T13, which may be caused by confined placental mosaicism, are associated with increased...

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Bibliographic Details
Published in:Prenatal diagnosis 2017-09, Vol.37 (9), p.938-939
Main Authors: Dotters‐Katz, Sarah K., Hardisty, Emily, Campbell, Erin, Vora, Neeta
Format: Article
Language:English
Subjects:
Adult
Cell-Free Nucleic Acids - blood
Deoxyribonucleic acid
Disorders
DNA
False Positive Reactions
Female
Humans
Hypertension
Hypertension, Pregnancy-Induced - diagnosis
Hypertension, Pregnancy-Induced - etiology
Hypertension, Pregnancy-Induced - genetics
Infant, Newborn
Mosaicism
Patau's syndrome
Placenta
Placenta - metabolism
Placenta - pathology
Pregnancy
Prenatal Diagnosis - methods
Risk
Risk Factors
Trisomy
Trisomy 13 Syndrome - diagnosis
Trisomy 13 Syndrome - genetics
Trisomy 13 Syndrome - metabolism
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Summary:What's already known about this topic? Trisomy 13 (T13) pregnancies are associated with increased risk of gestational hypertensive disorders (GHDs). It is unclear if false positive cell‐free DNA results for T13, which may be caused by confined placental mosaicism, are associated with increased risk for GHD. What does this study add? Among six women with false positive cell‐free DNA for T13, four developed GHD, raising the possibility that there may be an increased risk for GHD in women with false positive cell‐free DNA results for T13. © 2017 John Wiley & Sons, Ltd.
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.5105