Genetics and genetic testing for age-related macular degeneration

Considerable advances have been made in our understanding of age-related macular degeneration (AMD) genetics over the past decade. The genetic associations discovered to date are estimated to account for approximately half of AMD heritability, and functional studies of these variants have revealed n...

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Bibliographic Details
Published in:Eye (London) 2018-05, Vol.32 (5), p.849-857
Main Authors: Warwick, A., Lotery, A.
Format: Article
Language:English
Subjects:
Age
Genetic Predisposition to Disease
Genetic screening
Genetic Testing
Genetics
Heritability
Humans
Laboratory Medicine
Macular degeneration
Macular Degeneration - genetics
Medicine
Medicine & Public Health
Ophthalmology
Pharmaceutical Sciences/Technology
Review
Review Article
Risk Factors
Surgery
Surgical Oncology
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Summary:Considerable advances have been made in our understanding of age-related macular degeneration (AMD) genetics over the past decade. The genetic associations discovered to date are estimated to account for approximately half of AMD heritability, and functional studies of these variants have revealed new insights into disease pathogenesis, leading to the development of potential novel therapies. There is furthermore growing interest in genetic testing for predicting an individual’s risk of AMD and offering personalised preventive or therapeutic treatments. We review the progress made so far in AMD genetics and discuss the possible applications for genetic testing.
ISSN:0950-222X
1476-5454
DOI:10.1038/eye.2017.245