O-GlcNAcylation in women’s cancers: breast, endometrial and ovarian

O-GlcNAcylation is emerging as a critical regulatory post-translational modification, impacting proteins that regulate cell division, apoptosis, metabolism, cell signaling, and transcription. O-GlcNAc also affects biological homeostasis by integrating information coming from the environment, such as...

Full description

Saved in:
Bibliographic Details
Published in:Journal of bioenergetics and biomembranes 2018-06, Vol.50 (3), p.199-204
Main Authors: Trinca, Gloria M., Hagan, Christy R.
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Apoptosis
Biochemistry
Bioorganic Chemistry
Breast cancer
Cancer
Cell division
Chemistry
Chemistry and Materials Science
Endometrial cancer
Endometrium
Histology
Homeostasis
Metabolism
Mini-Review
Morphology
Neurodegenerative diseases
Neurological diseases
O-GlcNAcylation
Organic Chemistry
Ovarian cancer
Post-translation
Proteins
Transcription
Tumorigenesis
Uterine cancer
Uterus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:O-GlcNAcylation is emerging as a critical regulatory post-translational modification, impacting proteins that regulate cell division, apoptosis, metabolism, cell signaling, and transcription. O-GlcNAc also affects biological homeostasis by integrating information coming from the environment, such as nutrient conditions and extracellular stimuli, with cellular response. Aberrant O-GlcNAc modulation has been linked to metabolic and neurodegenerative diseases, as well as cancers. While many studies have highlighted the significance of O-GlcNAc in cancer, a specific function for O-GlcNAc during tumorigenesis remains unclear and seems to differ according to cancer type. Herein, we review the impact of altered O-GlcNAcylation in breast, ovarian and uterine cancers.
ISSN:0145-479X
1573-6881
DOI:10.1007/s10863-017-9730-z