Mechanistic insight into contextual TGF-β signaling

Transforming growth factor-β (TGF-β) controls a wide range of cellular functions by activating both SMADs and non-SMAD pathways. In different tissue or physiological environment, cellular responses to TGF-β can be diverse, even opposite. Complex regulations at the level of ligand mobilization, recep...

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Bibliographic Details
Published in:Current opinion in cell biology 2018-04, Vol.51, p.1-7
Main Author: Zhang, Ying E
Format: Article
Language:English
Subjects:
Humans
Signal Transduction
Smad Proteins - metabolism
Transforming Growth Factor beta - metabolism
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Summary:Transforming growth factor-β (TGF-β) controls a wide range of cellular functions by activating both SMADs and non-SMAD pathways. In different tissue or physiological environment, cellular responses to TGF-β can be diverse, even opposite. Complex regulations at the level of ligand mobilization, receptor presentation, and the network of intracellular signal transducers afford the TGF-β pathway with versatile means to induce precise cellular responses in accordance to specific contextual demands. This article summarizes recent development in how cells manage their responses to TGF-β through ligand activation, receptor abundance, as well as SMAD-dependent and SMAD-independent mechanisms.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2017.10.001