Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies

The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed and identified as 13% HA-87% TCP and 41% HA-59% TCP....

Full description

Saved in:
Bibliographic Details
Published in:Materials 2018-04, Vol.11 (4), p.595
Main Authors: Xidaki, Despoina, Agrafioti, Panagiota, Diomatari, Dimitra, Kaminari, Archontia, Tsalavoutas-Psarras, Eleftherios, Alexiou, Polyxeni, Psycharis, Vasilios, Tsilibary, Effie C, Silvestros, Spyridon, Sagnou, Marina
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Biocompatibility
Biomedical materials
Calcium phosphates
Hydroxyapatite
Surgical implants
Synthesis
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed and identified as 13% HA-87% TCP and 41% HA-59% TCP. All samples were treated with curcumin solutions, and the degree of curcumin loading and release was found to be proportional to the TCP content of the ceramic. No further cytotoxicity was observed upon MG-63 treatment with the curcumin-loaded ceramics. Finally, the alkaline phosphatase activity of the cells was found to increase with increasing content of TCP, which provides an encouraging proof of concept for the use of curcumin-loaded synthetic biomaterials in bone remodeling.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma11040595