Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank

AbstractObjectiveTo determine whether body mass index, body fat percentage, and waist circumference influence smoking status and intensity.DesignMendelian randomisation study.SettingUK Biobank, with replication of results from the Tobacco and Genetics (TAG) consortium.ParticipantsEuropean descent pa...

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Bibliographic Details
Published in:BMJ (Online) 2018-05, Vol.361, p.k1767-k1767
Main Authors: Carreras-Torres, Robert, Johansson, Mattias, Haycock, Philip C, Relton, Caroline L, Davey Smith, George, Brennan, Paul, Martin, Richard M
Format: Article
Language:English
Subjects:
Adipose tissue
Biological Specimen Banks
Body fat
Body Mass Index
Body measurements
Cigarettes
Female
Health behavior
Humans
Male
Mendelian Randomization Analysis
Middle Aged
Obesity
Obesity - epidemiology
Obesity - genetics
Obesity - psychology
Odds Ratio
Prevalence
Public health
Risk Factors
Smoking
Smoking - genetics
Smoking - psychology
Standard deviation
United Kingdom
Waist Circumference
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Summary:AbstractObjectiveTo determine whether body mass index, body fat percentage, and waist circumference influence smoking status and intensity.DesignMendelian randomisation study.SettingUK Biobank, with replication of results from the Tobacco and Genetics (TAG) consortium.ParticipantsEuropean descent participants from the UK Biobank cohort (n=372 791) and the TAG consortium (n=74 035).Main outcome measuresRisk of current and past smoking, number of cigarettes smoked per day, age of smoking initiation.ResultsThe Mendelian randomisation analysis indicated that each standard deviation increment in body mass index (4.6) increased the risk of being a smoker (odds ratio 1.18 (95% confidence interval 1.13 to 1.23), P
ISSN:0959-8138
1756-1833
DOI:10.1136/bmj.k1767