Intracranial source activity (eLORETA) related to scalp‐level asymmetry scores and depression status

Frontal EEG alpha asymmetry provides a promising index of depression risk, yet very little is known about the neural sources of alpha asymmetry. To identify these sources, this study examined alpha asymmetry using a distributed inverse solution: exact low resolution brain electromagnetic tomography...

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Bibliographic Details
Published in:Psychophysiology 2018-01, Vol.55 (1), p.n/a
Main Authors: Smith, Ezra E., Cavanagh, James F., Allen, John J. B.
Format: Article
Language:English
Subjects:
Adult
Alpha Rhythm
anhedonia
Asymmetry
depression
Depressive Disorder, Major - diagnostic imaging
Depressive Disorder, Major - psychology
Diagnostic and Statistical Manual of Mental Disorders
EEG
EEG alpha asymmetry
Electroencephalography
eLORETA
emotion
Female
Functional Laterality
Hedonic response
Humans
Magnetic Resonance Imaging - methods
Male
Mental depression
Precentral gyrus
Psychiatric Status Rating Scales
source estimation
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Summary:Frontal EEG alpha asymmetry provides a promising index of depression risk, yet very little is known about the neural sources of alpha asymmetry. To identify these sources, this study examined alpha asymmetry using a distributed inverse solution: exact low resolution brain electromagnetic tomography (eLORETA). Findings implicated a generator in lateral midfrontal regions that contributed to both surface asymmetry and depression risk. Participants with any lifetime history of depressive episodes were characterized by less left than right activity in the precentral gyrus and midfrontal gyrus. Anhedonia accounted for a significant portion of the relationship between alpha asymmetry and lifetime major depressive disorder. Results are suggestive of convergence between motivational and capability models of asymmetry and replicate results from experimental studies in a large resting‐state data set. The capability model of frontal alpha asymmetry is contextualized in terms of motor preparedness following emotional mobilization.
ISSN:0048-5772
1469-8986
1540-5958
DOI:10.1111/psyp.13019