Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism’s cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of var...

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Bibliographic Details
Published in:Archivum Immunologiae et Therapiae Experimentalis 2018-06, Vol.66 (3), p.211-220
Main Authors: Krata, Natalia, Zagożdżon, Radosław, Foroncewicz, Bartosz, Mucha, Krzysztof
Format: Article
Language:English
Subjects:
Biomarkers
Biomedical and Life Sciences
Biomedicine
Biopsy
Decision making
End-stage renal disease
Immunology
Kidney diseases
Kidney transplantation
Nephrology
Oxidative stress
Pharmacology/Toxicology
Review
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Summary:Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism’s cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. In nephrology, researchers are looking for alternative methods replacing the renal biopsy in patients with suspicion of chronic kidney disease (CKD). Currently, CKD is a frequent health problem in world population, which can lead to progressive loss of kidney function and eventually to end-stage renal disease. The course of CKD depends on the primary disease. It is assumed that one of the factors influencing the course of CKD might be OS. In the current work, we review whether monitoring the OS-associated biomarkers in nephrology patients can support the decision-making process regarding diagnosis, prognostication and treatment initiation.
ISSN:0004-069X
1661-4917
DOI:10.1007/s00005-017-0496-0