Acetyl-CoA-directed gene transcription in cancer cells

Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497-511) in this issue of demonstrates that acetyl-CoA can promote the up-regulation of cell migration- and adhes...

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Published in:Genes & development 2018-04, Vol.32 (7-8), p.463-465
Main Authors: Martínez-Reyes, Inmaculada, Chandel, Navdeep S
Format: Article
Language:English
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Summary:Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497-511) in this issue of demonstrates that acetyl-CoA can promote the up-regulation of cell migration- and adhesion-related genes in glioblastoma by controlling Ca -NFAT (nuclear factor of activated T cells) signaling.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.315168.118