Spontaneous acalculous gallbladder perforation in a man secondary to chemotherapy and radiation: A rare case report

Gallbladder perforation is a serious clinical condition and associated with high morbidity and mortality. A definitive diagnosis is contentious before surgery. We herein report a case of perforation of the gallbladder neck secondary to chemotherapy and radiation for nasopharyngeal carcinoma patient....

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Published in:Medicine (Baltimore) 2018-05, Vol.97 (19), p.e0674-e0674
Main Authors: Zhang, Jungang, Shen, Guoliang, Shi, Ying, Zhang, Chengwu, Hong, Defei, Jin, Li, Yang, Hongguo, Sun, Wei, Cai, Hanhui, Hu, Zhiming, Wu, Weiding
Format: Article
Language:English
Subjects:
Antineoplastic Agents - adverse effects
Carcinoma - drug therapy
Carcinoma - radiotherapy
Cisplatin - adverse effects
Clinical Case Report
Gallbladder Diseases - etiology
Gallbladder Diseases - surgery
Humans
Laparoscopy
Male
Middle Aged
Nasopharyngeal Neoplasms - drug therapy
Nasopharyngeal Neoplasms - radiotherapy
Radiotherapy - adverse effects
Rupture, Spontaneous
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Summary:Gallbladder perforation is a serious clinical condition and associated with high morbidity and mortality. A definitive diagnosis is contentious before surgery. We herein report a case of perforation of the gallbladder neck secondary to chemotherapy and radiation for nasopharyngeal carcinoma patient. Gallbladder perforation secondary to chemotherapy and radiation. To decrease the mortality associated with gallbladder perforation, Laparoscopic cholecystectomy and peritoneal lavage were performed followed for gallbladder perforation patient because of chemotherapy and radiation. The patient recovered fully without serious complication and discharged on the 10th postoperative day. A pathological examination of the resected gallbladder revealed cholecystitis in the thinning of the neck. Early diagnosis and surgical intervention of gallbladder perforation in relation to asopharyngeal carcinoma chemotherapy and radiation are of prime importance. The laparoscopic procedure is safe and feasible in the selected patients.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000010674