CaV1.2 Calcium Channels: Just Cut Out to Be Regulated?

Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis et al. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the c...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2014-06, Vol.82 (5), p.939-940
Main Authors: Groth, Rachel D., Tirko, Natasha N., Tsien, Richard W.
Format: Article
Language:English
Subjects:
Animals
Calcium
Calcium Channels, L-Type - metabolism
Female
Gene expression
Male
Neurons
Neurons - metabolism
Proteins
Proteolysis
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Summary:Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis et al. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2014.05.030