The TFOS International Workshop on Contact Lens Discomfort: report of the subcommittee on neurobiology

This report characterizes the neurobiology of the ocular surface and highlights relevant mechanisms that may underpin contact lens-related discomfort. While there is limited evidence for the mechanisms involved in contact lens-related discomfort, neurobiological mechanisms in dry eye disease, the in...

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Bibliographic Details
Published in:Investigative ophthalmology & visual science 2013-10, Vol.54 (11), p.TFOS71-TFOS97
Main Authors: Stapleton, Fiona, Marfurt, Carl, Golebiowski, Blanka, Rosenblatt, Mark, Bereiter, David, Begley, Carolyn, Dartt, Darlene, Gallar, Juana, Belmonte, Carlos, Hamrah, Pedram, Willcox, Mark
Format: Article
Language:English
Subjects:
Contact Lenses - adverse effects
Eye Diseases - etiology
Focus Groups
Humans
Neurobiology
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Summary:This report characterizes the neurobiology of the ocular surface and highlights relevant mechanisms that may underpin contact lens-related discomfort. While there is limited evidence for the mechanisms involved in contact lens-related discomfort, neurobiological mechanisms in dry eye disease, the inflammatory pathway, the effect of hyperosmolarity on ocular surface nociceptors, and subsequent sensory processing of ocular pain and discomfort have been at least partly elucidated and are presented herein to provide insight in this new arena. The stimulus to the ocular surface from a contact lens is likely to be complex and multifactorial, including components of osmolarity, solution effects, desiccation, thermal effects, inflammation, friction, and mechanical stimulation. Sensory input will arise from stimulation of the lid margin, palpebral and bulbar conjunctiva, and the cornea.
ISSN:1552-5783
0146-0404
1552-5783
DOI:10.1167/iovs.13-13226