Lack of Tumorigenicity of Aminopyrine Orally Administered to B6C3F1 Mice

To test the tumorigenic potential of aminopyrine, an antipyretic analgesic, it was administered in drinking water at levels of 0 (control), 0.04 and 0.08% to 50 male and 50 female B6C3F1, mice for 100 weeks, and the mice were subsequently maintained without aminopyrine for a further 4 weeks. The mos...

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Bibliographic Details
Published in:Japanese Journal of Cancer Research 1990-02, Vol.81 (2), p.122-128
Main Authors: Inai, Kouki, Kobuke, Toshihiro, Fujihara, Megumu, Yonehara, Shuji, Takemoto, Tsuyoshi, Tsuya, Takafumi, Yamamoto, Atsushi, Tachiyama, Yoshiro, Izumi, Kumiko, Tokuoka, Shoji
Format: Article
Language:English
Subjects:
Administration, Oral
Aminopyrine
Aminopyrine - toxicity
Animals
B6C3F1 mouse
Biological and medical sciences
Female
Liver - drug effects
Liver - pathology
Liver Neoplasms, Experimental - chemically induced
Lymphoma - chemically induced
Male
Medical sciences
Mice
Mice, Inbred Strains
Neoplasms, Experimental - chemically induced
Sodium Nitrite - toxicity
Tumorigenicity
Tumors
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Summary:To test the tumorigenic potential of aminopyrine, an antipyretic analgesic, it was administered in drinking water at levels of 0 (control), 0.04 and 0.08% to 50 male and 50 female B6C3F1, mice for 100 weeks, and the mice were subsequently maintained without aminopyrine for a further 4 weeks. The most frequent types of tumor, in both treated and control groups, were hepatocellular tumor in male mice and malignant lymphoma/lymphoid leukemia in female mice. No statistically significant differences were observed in the incidences of these tumors between treated and control groups. The incidences of several other tumors in male and female mice also showed no statistically significant differences between treated and control groups. Therefore, no tumorigenic effect of orally administered aminopyrine in B6C3F1 mice was apparent in the present study.
ISSN:0910-5050
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1990.tb02537.x