Role of FcαR EC2 region in extracellular membrane localization

The FcαR receptor (CD89) binds to the constant region of Immunoglobulin (Ig) A to mediate mucosal immunity [1-2]. FcαR consist of five exons: two that code for the signal peptide regions S1 & S2, two for the extracellular regions EC1 and EC2, and the final exon for the transmembrane/cytoplasmic...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2018-03, Vol.17 (5), p.669-670
Main Authors: Phua, Ser-Xian, Lua, Wai-Heng, Gan, Samuel Ken-En
Format: Article
Language:English
Subjects:
EC2
FCAR
Letter to the Editor
signal peptide
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Summary:The FcαR receptor (CD89) binds to the constant region of Immunoglobulin (Ig) A to mediate mucosal immunity [1-2]. FcαR consist of five exons: two that code for the signal peptide regions S1 & S2, two for the extracellular regions EC1 and EC2, and the final exon for the transmembrane/cytoplasmic tail region [3]. Previously, we reported that the EC1 region plays an essential role for extracellular membrane localization of the receptor [4], where the absence of EC1 would prevent the variants from localizing to the cell surface, even with a full signal peptide. In the case of FcαR Variant 4 (lacking the S2 region only), there was some "leakiness" to membrane surface localization.
ISSN:1538-4101
1551-4005
DOI:10.1080/15384101.2018.1444236