An exploration of bioactive peptides: My collaboration with Ervin G. Erdös

This paper provides a brief historical sketch of the science of biologically active peptides. It also offers the story of how Ervin G. Erdös, a pioneer in the study of metabolism of various peptides, influenced me through collaborations that span many years. I worked in Dr. Erdös's research lab...

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Bibliographic Details
Published in:The Journal of biological chemistry 2018-05, Vol.293 (21), p.7907-7915
Main Author: Igić, Rajko
Format: Article
Language:English
Subjects:
angiotensin
angiotensin II
angiotensin-converting enzyme (ACE)
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Erdös
Ervin G. Erdös
History, 20th Century
History, 21st Century
Humans
kallikrein
kallikrein-kinin
kinase II
Peptide Fragments - history
Peptide Fragments - pharmacology
Peptidyl-Dipeptidase A - chemistry
Reflections
renin angiotensin system
Renin-Angiotensin System - drug effects
retina substance P
vascular biology
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Summary:This paper provides a brief historical sketch of the science of biologically active peptides. It also offers the story of how Ervin G. Erdös, a pioneer in the study of metabolism of various peptides, influenced me through collaborations that span many years. I worked in Dr. Erdös's research laboratories in Oklahoma City, Dallas, and Chicago, and we shared research interests through visits across the Atlantic between the former Yugoslavia and the United States. Among other findings, we discovered angiotensin-converting enzyme in the retina, which opened up a new research direction for many scientists interested in serious ocular diseases. This tribute to my mentor paints a portrait of a man who, in addition to his dedication to science and his seminal discoveries about the metabolism of peptides, took the time to invest in training many young scientists. His fine personal qualities explain why all of those who worked with him hold him in such high regard.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.X118.003433