Genome-Wide Identification and Analysis of Arabidopsis Sodium Proton Antiporter (NHX) and Human Sodium Proton Exchanger (NHE) Homologs in Sorghum bicolor

Na⁺ transporters play an important role during salt stress and development. The present study is aimed at genome-wide identification, in silico analysis of sodium-proton antiporter (NHX) and sodium-proton exchanger (NHE)-type transporters in and their expression patterns under varied abiotic stress...

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Published in:Genes 2018-05, Vol.9 (5), p.236
Main Authors: Hima Kumari, P, Anil Kumar, S, Ramesh, Katam, Sudhakar Reddy, Palakolanu, Nagaraju, M, Bhanu Prakash, A, Shah, Trushar, Henderson, Ashley, Srivastava, Rakesh K, Rajasheker, G, Chitikineni, A, Varshney, Rajeev K, Rathnagiri, P, Lakshmi Narasu, M, Kavi Kishor, P B
Format: Article
Language:English
Subjects:
Abiotic stress
Amiloride
Calcineurin
Cbl protein
Chromosome 2
Drought
Gene expression
Genomes
Na+/H+-exchanging ATPase
Phylogeny
Protein interaction
Protein kinase
Proteins
Sodium
Sorghum
Sorghum bicolor
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Summary:Na⁺ transporters play an important role during salt stress and development. The present study is aimed at genome-wide identification, in silico analysis of sodium-proton antiporter (NHX) and sodium-proton exchanger (NHE)-type transporters in and their expression patterns under varied abiotic stress conditions. In , seven and nine homologs were identified. Amiloride (a known inhibitor of Na⁺/H⁺ exchanger activity) binding motif was noticed in both types of the transporters. Chromosome 2 was found to be a hotspot region with five sodium transporters. Phylogenetic analysis inferred six ortholog and three paralog groups. To gain an insight into functional divergence of / transporters, real-time gene expression was performed under salt, drought, heat, and cold stresses in embryo, root, stem, and leaf tissues. Expression patterns revealed that both and are responsive either to single or multiple abiotic stresses. The predicted protein⁻protein interaction networks revealed that only SbNHX7 is involved in the calcineurin B-like proteins (CBL)- CBL interacting protein kinases (CIPK) pathway. The study provides insights into the functional divergence of / transporter genes with tissue specific expressions in under different abiotic stress conditions.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes9050236