Effect of Collagen-Polycaprolactone Nanofibers Matrix Coating on the In Vitro Cytocompatibility and In Vivo Bone Responses of Titanium

The objective of this study was to improve the biomechanical performance of titanium (Ti) using a biocompatible electrospun nanofiber matrix. The study is based on the hypothesis that coating a Ti surface with a nanofiber matrix (NFM) made of collagen (CG) and polycaprolactone (PCL) electrospun nano...

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Bibliographic Details
Published in:Journal of medical and biological engineering 2018-04, Vol.38 (2), p.197-210
Main Authors: Khandaker, Morshed, Riahinezhad, Shahram, Sultana, Fariha, Morris, Tracy, Wolf, Roman, Vaughan, Melville
Format: Article
Language:English
Subjects:
Adsorption
Biocompatibility
Biomechanics
Biomedical Engineering and Bioengineering
Biomedical materials
Cell adhesion
Cell adhesion & migration
Cell Biology
Coating effects
Coatings
Collagen
Connective tissues
Electrospinning
Engineering
Imaging
In vivo methods and tests
Mineralization
Nanofibers
Original Article
Polycaprolactone
Properties (attributes)
Protein adsorption
Radiology
Shear strength
Surface chemistry
Surface roughness
Surgical implants
Therapeutic applications
Titanium
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Summary:The objective of this study was to improve the biomechanical performance of titanium (Ti) using a biocompatible electrospun nanofiber matrix. The study is based on the hypothesis that coating a Ti surface with a nanofiber matrix (NFM) made of collagen (CG) and polycaprolactone (PCL) electrospun nanofibers could increase the mechanical fixation of Ti/bone by improving the surface and cytocompatibility properties of Ti. This study prepared Ti samples with and without CG-PCL NFM coatings. This study determined the in vitro effects of each group of Ti samples on the surface topography and cytocompatibility (osteoblast cell adhesion, proliferation, mineralization and protein adsorption) properties. This study also determined in vivo interface shear strength and bone volume fraction of each group of Ti samples with bone using a rabbit model. This study found that the CG-PCL NFM coating on Ti improved the surface roughness, osteoblast cell adhesion, proliferation, mineralization and protein adsorption properties of Ti. In vivo studies found that interface shear strength of CG-PCL NFM-coated Ti/bone samples was significantly higher compared to those values of control Ti/bone samples ( p value 
ISSN:1609-0985
2199-4757
DOI:10.1007/s40846-017-0312-7