Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid hydroperoxides. There has been significant research on the pathways leading to the accumulation of oxidized lipids, but the downstream effects and how lipid peroxides cause cell death during ferroptosis remain a...

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Bibliographic Details
Published in:Scientific reports 2018-03, Vol.8 (1), p.5155-11, Article 5155
Main Authors: Agmon, Eran, Solon, Jérôme, Bassereau, Patricia, Stockwell, Brent R.
Format: Article
Language:English
Subjects:
119/118
631/114/2397
631/80/82
Apoptosis
Biochemistry, Molecular Biology
Biophysics
Cell death
Cellular Biology
Condensed Matter
Ferroptosis
Humanities and Social Sciences
Life Sciences
Lipid membranes
Lipid peroxidation
Lipids
Molecular modelling
Mortality
multidisciplinary
Peroxidation
Physics
Science
Science (multidisciplinary)
Soft Condensed Matter
Subcellular Processes
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Summary:Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid hydroperoxides. There has been significant research on the pathways leading to the accumulation of oxidized lipids, but the downstream effects and how lipid peroxides cause cell death during ferroptosis remain a major puzzle. We evaluated key features of ferroptosis in newly developed molecular dynamics models of lipid membranes to investigate the biophysical consequences of lipid peroxidation, and generated hypotheses about how lipid peroxides contribute to cell death during ferroptosis.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-23408-0