P2X receptor channels in chronic pain pathways

Chronic pain is a highly prevalent debilitating condition for which treatment options remain limited for many patients. Ionotropic ATP signalling through excitatory and calcium‐permeable P2X receptor channels is now rightfully considered as a critical player in pathological pain generation and maint...

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Bibliographic Details
Published in:British journal of pharmacology 2018-06, Vol.175 (12), p.2219-2230
Main Authors: Bernier, Louis‐Philippe, Ase, Ariel R, Séguéla, Philippe
Format: Article
Language:English
Subjects:
Animals
Calcium
Calcium channels
Calcium permeability
Cancer
Chronic pain
Chronic Pain - metabolism
Humans
Inflammation
Ion channels
Neuralgia
Pain
Receptor channels
Receptors, Purinergic P2X7 - metabolism
Review
Signal transduction
Structural analysis
Structure-function relationships
Themed Section: Review
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Summary:Chronic pain is a highly prevalent debilitating condition for which treatment options remain limited for many patients. Ionotropic ATP signalling through excitatory and calcium‐permeable P2X receptor channels is now rightfully considered as a critical player in pathological pain generation and maintenance; therefore, their selective targeting represents a therapeutic opportunity with promising yet untapped potential. Recent advances in the structural, functional and pharmacological characterization of rodent and human ATP‐gated P2X receptor channels have shed brighter light on the role of specific subtypes in the pathophysiology of chronic inflammatory, neuropathic or cancer pain. Here, we will review the contribution of P2X3, P2X4 and P2X7 receptors to chronic pain and discuss the opportunities and challenges associated with the pharmacological manipulation of their function. Linked Articles This article is part of a themed section on Recent Advances in Targeting Ion Channels to Treat Chronic Pain. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.12/issuetoc
ISSN:0007-1188
1476-5381
DOI:10.1111/bph.13957