Paraneoplastic IgA Vasculitis in an Adult with Lung Adenocarcinoma

A 50-year-old man with lung adenocarcinoma (c-T1aN2M1b) experienced reddish purpura mainly on the lower legs after receiving 12 cycles of second-line chemotherapy with docetaxel. There was tumor enlargement on computed tomography performed to assess the therapeutic response, so paraneoplastic IgA va...

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Bibliographic Details
Published in:Internal Medicine 2018/05/01, Vol.57(9), pp.1273-1276
Main Authors: Ota, Shuji, Haruyama, Terunobu, Ishihara, Masashi, Natsume, Maika, Fukasawa, Yoko, Sakamoto, Takahiko, Tanzawa, Shigeru, Usui, Ryo, Honda, Takeshi, Ichikawa, Yasuko, Watanabe, Kiyotaka, Sasajima, Yuko, Seki, Nobuhiko
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - complications
Adenocarcinoma of Lung
Biopsy
Case Report
Chemotherapy
Complications
Computed tomography
Diagnosis, Differential
Differential diagnosis
Docetaxel
drug eruption
Exanthema - chemically induced
Exanthema - diagnostic imaging
Hemorrhage
Histology
Humans
IgA vasculitis
Immunoglobulin A
Internal medicine
lung cancer
Lung Neoplasms - complications
Lungs
Male
Malignancy
Middle Aged
Mucosa
Paraneoplastic Syndromes - chemically induced
Paraneoplastic Syndromes - diagnostic imaging
Paraneoplastic Syndromes - therapy
paraneoplastic vasculitis
Purpura
Purpura - chemically induced
Purpura - diagnostic imaging
Skin diseases
Taxoids - adverse effects
Taxoids - therapeutic use
Treatment Outcome
Vasculitis
Vasculitis - chemically induced
Vasculitis - diagnostic imaging
Vasculitis - therapy
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Summary:A 50-year-old man with lung adenocarcinoma (c-T1aN2M1b) experienced reddish purpura mainly on the lower legs after receiving 12 cycles of second-line chemotherapy with docetaxel. There was tumor enlargement on computed tomography performed to assess the therapeutic response, so paraneoplastic IgA vasculitis was considered. IgA vasculitis was diagnosed based on a biopsy of the skin lesion and histology of an upper gastrointestinal hemorrhagic mucosal erosion. As IgA vasculitis can lead to serious gastrointestinal or systemic complications, IgA vasculitis should be considered as a differential diagnosis for rashes in patients with malignancy.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.9651-17