Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy

Skeletal muscle hypertrophy is a widely sought exercise adaptation to counteract the muscle atrophy of aging and disease, or to improve athletic performance. While this desired muscle enlargement is a well-known adaptation to resistance exercise training (RT), the mechanistic underpinnings are not f...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2018-06, Vol.8 (6), p.a029751
Main Authors: Bamman, Marcas M, Roberts, Brandon M, Adams, Gregory R
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Exercise - physiology
Humans
Mechanotransduction, Cellular
Muscle Fibers, Skeletal - metabolism
Muscle, Skeletal - growth & development
Muscle, Skeletal - metabolism
Resistance Training
Ribosomes - metabolism
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Summary:Skeletal muscle hypertrophy is a widely sought exercise adaptation to counteract the muscle atrophy of aging and disease, or to improve athletic performance. While this desired muscle enlargement is a well-known adaptation to resistance exercise training (RT), the mechanistic underpinnings are not fully understood. The purpose of this review is thus to provide the reader with a summary of recent advances in molecular mechanisms-based on the most current literature-that are thought to promote RT-induced muscle hypertrophy. We have therefore focused this discussion on the following areas of fertile investigation: ribosomal function and biogenesis, muscle stem (satellite) cell activity, transcriptional regulation, mechanotransduction, and myokine signaling.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a029751