Dynamics of Posttranslational Modification Systems: Recent Progress and Future Directions

Posttranslational modification of proteins is important for signal transduction, and hence significant effort has gone toward understanding how posttranslational modification networks process information. This involves, on the theory side, analyzing the dynamical systems arising from such networks....

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Bibliographic Details
Published in:Biophysical journal 2018-02, Vol.114 (3), p.507-515
Main Authors: Conradi, Carsten, Shiu, Anne
Format: Article
Language:English
Subjects:
Biophysical
Dynamical systems
Information processing
Intermediates
Networks
Oscillations
Proteins
Signal transduction
Transcription factors
Transduction
Variables
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Summary:Posttranslational modification of proteins is important for signal transduction, and hence significant effort has gone toward understanding how posttranslational modification networks process information. This involves, on the theory side, analyzing the dynamical systems arising from such networks. Which networks are, for instance, bistable? Which networks admit sustained oscillations? Which parameter values enable such behaviors? In this Biophysical Perspective, we highlight recent progress in this area and point out some important future directions. Along the way, we summarize several techniques for analyzing general networks, such as eliminating variables to obtain steady-state parameterizations, and harnessing results on how incorporating intermediates affects dynamics.
ISSN:0006-3495
1542-0086
DOI:10.1016/j.bpj.2017.11.3787