The use of platelet-rich fibrin with platelet-rich plasma support meniscal repair surgery

• Published in: Journal of orthopaedics 2018-06, Vol.15 (2), p.711-720
• Main Authors: Kemmochi, Masahiko, Sasaki, Shigeru, Takahashi, Masako, Nishimura, Tomitaka, Aizawa, Chisa, Kikuchi, Jun
• Format: Article
• Language: English
• Subjects: Arthroscopy; Meniscal repair; Orthopedics; Platelet-rich fibrin; Platelet-rich plasma; Regenerative medicine
• ISSN: 0972-978X; 0972-978X
• DOI: 10.1016/j.jor.2018.05.006

Abstract Introduction Platelet-rich fibrin (PRF) is the only autologous blood product that releases growth factors and has scaffolding properties. We hypothesized that the use of PRF and Platelet-rich plasma (PRP) would improve operative results, including the recovery of function and repaired meniscus. Materials and Methods Seventeen patients underwent arthroscopic meniscus repair with PRF and PRP (PRF group) using our novel device for the injection of the PRF into the joint. Another five patients as a control group underwent meniscal repair without PRF and PRP (non-PRF group). The groups were compared in terms of clinical results (Tegner Activity Level Scale, Lysholm Knee Scoring Scale, and International Knee Documentation Committee [IKDC] scores) and changes in magnetic resonance imaging (MRI) findings before surgery and 6 months after surgery. Results The Lysholm and IKDC scores improved in all patients postoperatively. However, there was no significant differencies in the postoperative score between the PRF group and the non-PRF group. Follow-up MRI findings did not clearly show improvements. Conclusions PRF and PRP are autologous, safe, and cost-effective sources of growth factors. Therefore, we propose a new application of PRF and PRP for autologous transplantation in meniscus repair surgery.