High-intensity binge drinking is associated with alterations in spontaneous neural oscillations in young adults

• Published in: Alcohol (Fayetteville, N.Y.) N.Y.), 2018-08, Vol.70, p.51-60
• Main Authors: Affan, Rifqi O., Huang, Siyuan, Cruz, Stephen M., Holcomb, Lee A., Nguyen, Edward, Marinkovic, Ksenija
• Format: Article
• Language: English
• Subjects: Adults; Alcohol; Alcohol use; Alcoholic beverages; Alcoholism; Alpha; Alpha peak frequency; Anxiety; Beta; Binge drinking; Binge Drinking - physiopathology; Binge Drinking - psychology; Brain; Brain - physiopathology; Brain research; Brain Waves - physiology; Cerebral cortex; Cognitive ability; Dependence; Drinking; Drinking behavior; Drug abuse; Drug dependence; EEG; Electroencephalography; Female; Genetics; Humans; Information processing; Male; Memory; Mental depression; Neurobiology; Oscillations; Peak frequency; Personality; Resting-state EEG; Thalamus; Theta; Theta rhythms; Young Adult; Young adults
• ISSN: 0741-8329; 1873-6823
• DOI: 10.1016/j.alcohol.2018.01.002

Heavy episodic alcohol consumption (also termed binge drinking) contributes to a wide range of health and cognitive deficits, but the associated brain-based indices are poorly understood. The current study used electroencephalography (EEG) to examine spontaneous neural oscillations in young adults as a function of quantity, frequency, and the pattern of their alcohol consumption. Sixty-one young adults (23.4 ± 3.4 years of age) were assigned to binge drinking (BD) and light drinking (LD) groups that were equated on gender, race/ethnic identity, age, educational background, and family history of alcoholism. EEG activity was recorded during eyes-open and eyes-closed resting conditions. Each participant's alpha peak frequency (APF) was used to calculate absolute power in individualized theta and alpha frequency bands, with a canonical frequency range used for beta. APF was slower by 0.7 Hz in BD, especially in individuals engaging in high-intensity drinking, but there were no changes in alpha power. BD also exhibited higher frontal theta and beta power than LD. Alpha slowing and increased theta power in BD remained after accounting for depression, anxiety, and personality characteristics, while elevated beta power covaried with sensation seeking. Furthermore, APF slowing and theta power correlated with various measures of alcohol consumption, including binge episodes and blackouts, but not with measures of working and episodic memory, cognitive flexibility, processing speed, or personality variables, suggesting that these physiological changes may be modulated by high-intensity alcohol intake. These results are consistent with studies of alcohol-use disorder (AUD) and support the hypothesis that binge drinking is a transitional stage toward alcohol dependence. The observed thalamocortical dysrhythmia may be indicative of an excitatory-inhibitory imbalance in BD and may potentially serve as an index of the progressive development of AUD, with a goal of informing possible interventions to minimize alcohol's deleterious effects on the brain. •Binge drinking is associated with alpha slowing and increased theta and beta power.•Alpha slowing in young adults is especially prominent at hazardous drinking levels.•Thalamocortical dysregulation may reflect a transition toward alcohol-use disorder.