Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds

The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and acidic fibroblast growth factor (aFGF) on the healing of diabetic foot wounds. A total of 199 patients with diabetic foot ulcers were recruited and randomly divided into four groups: A recombinant human E...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2018-06, Vol.15 (6), p.5365-5370
Main Authors: Xu, Jiasheng, Min, Dinghong, Guo, Guanghua, Liao, Xincheng, Fu, Zhonghua
Format: Article
Language:English
Subjects:
Antibiotics
Burn treatment
Care and treatment
Diabetes
Diabetic foot
Epidermal growth factor
Epidermal growth factors
Fibroblast growth factors
Fibroblasts
Foot diseases
Health aspects
Methods
Patients
Recombinant proteins
Statistical analysis
Studies
Wound care
Wound healing
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Summary:The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and acidic fibroblast growth factor (aFGF) on the healing of diabetic foot wounds. A total of 199 patients with diabetic foot ulcers were recruited and randomly divided into four groups: A recombinant human EGF group (n=50), an aFGF group (n=50), a combined EGF and aFGF group (n=50) and a normal saline control group (n=49). Patients in all groups received a daily dressing change and growth factor reagents were applied topically when dressing. To observe the time required for each stage of wound healing, the epidermal healing rate and granulation tissue growth were recorded. Following 3-4 days of treatment, the wound healing stage was similar in all groups. Later stages (following 4 days) of wound healing were achieved significantly faster in the combined group compared with the control group (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.6131