Initial observations on using magnesium metal in peripheral nerve repair

Biodegradable magnesium metal filaments placed inside biodegradable nerve conduits might provide the physical guidance support needed to improve the rate and extent of regeneration of peripheral nerves across injury gaps. In this study, we examined basic issues of magnesium metal resorption and bioc...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomaterials applications 2015-03, Vol.29 (8), p.1145-1154
Main Authors: Vennemeyer, JJ, Hopkins, T, Hershcovitch, M, Little, KD, Hagen, MC, Minteer, D, Hom, DB, Marra, K, Pixley, SK
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Biocompatible Materials
Conduits
Degradation
Filaments
Hydrogels
Keratins
Magnesium
Male
Materials Testing
Muscle, Skeletal - innervation
Muscle, Skeletal - pathology
Nerve Regeneration
Nerves
Peripheral Nerve Injuries - metabolism
Peripheral Nerve Injuries - pathology
Peripheral Nerve Injuries - surgery
Peripheral nerves
Polyesters
Rats
Rats, Inbred Lew
Saline
Sciatic Nerve - injuries
Sciatic Nerve - metabolism
Sciatic Nerve - surgery
Surgical implants
X-Ray Microtomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biodegradable magnesium metal filaments placed inside biodegradable nerve conduits might provide the physical guidance support needed to improve the rate and extent of regeneration of peripheral nerves across injury gaps. In this study, we examined basic issues of magnesium metal resorption and biocompatibility by repairing sub-critical size gap injuries (6 mm) in one sciatic nerve of 24 adult male Lewis rats. Separated nerve stumps were connected with poly(caprolactone) nerve conduits, with and without magnesium filaments (0.25 mm diameter, 10 mm length), with two different conduit filler substances (saline and keratin hydrogel). At 6 weeks after implantation, magnesium degradation was examined by micro-computed tomography and histological analyses. Magnesium degradation was significantly greater when the conduits were filled with an acidic keratin hydrogel than with saline (p 
ISSN:0885-3282
1530-8022
DOI:10.1177/0885328214553135