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Retrospective review of neurodevelopmental outcomes in infants treated for neonatal abstinence syndrome
Objective: Little is known about developmental outcomes in neonatal abstinence syndrome (NAS). We hypothesized that children treated for NAS would score lower than the normative sample on the Bayley Scales of Infant Development, 3rd edition. Study design: We performed a retrospective cohort study of...
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| Published in: | Journal of perinatology 2018-05, Vol.38 (5), p.587-592 |
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| container_end_page | 592 |
| container_issue | 5 |
| container_start_page | 587 |
| container_title | Journal of perinatology |
| container_volume | 38 |
| creator | Merhar, Stephanie L. McAllister, Jennifer M. Wedig-Stevie, Kathryn E. Klein, Amy C. Meinzen-Derr, Jareen Poindexter, Brenda B. |
| description | Objective:
Little is known about developmental outcomes in neonatal abstinence syndrome (NAS). We hypothesized that children treated for NAS would score lower than the normative sample on the Bayley Scales of Infant Development, 3rd edition.
Study design:
We performed a retrospective cohort study of 87 infants treated for NAS and evaluated at 2 years of age.
Results:
Children treated for NAS scored significantly lower than the norm (mean 100) on all 3 subscales (cognitive mean 96.5, language mean 93.8, motor mean 94.0, all
p
|
| doi_str_mv | 10.1038/s41372-018-0088-9 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5999528</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A572593140</galeid><sourcerecordid>A572593140</sourcerecordid><originalsourceid>FETCH-LOGICAL-c594t-38075541f984eb5228c5db8428499fc51fdb98e01f778b2d1d96573a3b5eb4c23</originalsourceid><addsrcrecordid>eNp1kl1rFDEUhoModq3-AG9kQPBuaj43yY1Qil9QEESvQyZzspsyk6xJZqX_3ixb2y4oCQRynvflnORF6DXBFwQz9b5wwiTtMVE9xkr1-glaES7XvRCcPUUrLDnrFePrM_SilBuMD0X5HJ1RLYigVKzQ5jvUnMoOXA176DLsA_zuku8iLDmNsIcp7WaI1U5dWqpLM5QuxLa9jbV0NYOtMHY-5SZJ0R5AO5QaIkQHXbmNY26il-iZt1OBV3fnOfr56eOPqy_99bfPX68ur3snNK89U1i25onXisPQWlROjIPiVHGtvRPEj4NWgImXUg10JKNeC8ksGwQM3FF2jj4cfXfLMMPoWufZTmaXw2zzrUk2mNNKDFuzSXsjtNaCqmbw9s4gp18LlGpu0pJj69lQLDheY8LYA7WxE5j2GKmZuTkUZy6FpEIzwnGjLv5BtTXCHFyK4EO7PxG8eyTYgp3qtqRpqSHFcgqSI-ja55UM_n5Cgs0hG-aYDdOyYQ7ZMLpp3jx-mnvF3zA0gB6B0kpxA_lh9P-7_gHxxMUV</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2054060133</pqid></control><display><type>article</type><title>Retrospective review of neurodevelopmental outcomes in infants treated for neonatal abstinence syndrome</title><source>Springer Link</source><creator>Merhar, Stephanie L. ; McAllister, Jennifer M. ; Wedig-Stevie, Kathryn E. ; Klein, Amy C. ; Meinzen-Derr, Jareen ; Poindexter, Brenda B.</creator><creatorcontrib>Merhar, Stephanie L. ; McAllister, Jennifer M. ; Wedig-Stevie, Kathryn E. ; Klein, Amy C. ; Meinzen-Derr, Jareen ; Poindexter, Brenda B.</creatorcontrib><description>Objective:
Little is known about developmental outcomes in neonatal abstinence syndrome (NAS). We hypothesized that children treated for NAS would score lower than the normative sample on the Bayley Scales of Infant Development, 3rd edition.
Study design:
We performed a retrospective cohort study of 87 infants treated for NAS and evaluated at 2 years of age.
Results:
Children treated for NAS scored significantly lower than the norm (mean 100) on all 3 subscales (cognitive mean 96.5, language mean 93.8, motor mean 94.0, all
p
< 0.03). Children who lived with foster/adoptive families at follow up had higher cognitive scores (median 100 vs. 95,
p
= 0.03) than those who lived with biological relatives, and were less likely to have motor scores <85 (
p
= 0.02). Eight percent of children required treatment for strabismus.
Conclusions:
Children treated for NAS are at risk for lower developmental scores and higher rates of strabismus at age 2 than the general population.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-018-0088-9</identifier><identifier>PMID: 29515225</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/409 ; 692/700/1720 ; Adoptive families ; Analysis ; Babies ; Birth weight ; Child Development ; Child, Preschool ; Children ; Children & youth ; Cognition ; Cognitive ability ; Developmental Disabilities - etiology ; Disabled Children - statistics & numerical data ; Diseases ; Drug withdrawal ; Feces ; Female ; Foster care ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infants ; Infants (Newborn) ; Language Development ; Male ; Medicine ; Medicine & Public Health ; Morphine ; Mothers ; Motor Skills ; Narcotics ; Neonatal abstinence syndrome ; Neonatal Abstinence Syndrome - complications ; Neonatal Abstinence Syndrome - therapy ; Neonates ; Newborn babies ; Ohio ; Pediatric research ; Pediatric Surgery ; Pediatrics ; Primary care ; Retrospective Studies ; Strabismus ; Strabismus - etiology ; Toxicology</subject><ispartof>Journal of perinatology, 2018-05, Vol.38 (5), p.587-592</ispartof><rights>Nature America, Inc., part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-38075541f984eb5228c5db8428499fc51fdb98e01f778b2d1d96573a3b5eb4c23</citedby><cites>FETCH-LOGICAL-c594t-38075541f984eb5228c5db8428499fc51fdb98e01f778b2d1d96573a3b5eb4c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29515225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merhar, Stephanie L.</creatorcontrib><creatorcontrib>McAllister, Jennifer M.</creatorcontrib><creatorcontrib>Wedig-Stevie, Kathryn E.</creatorcontrib><creatorcontrib>Klein, Amy C.</creatorcontrib><creatorcontrib>Meinzen-Derr, Jareen</creatorcontrib><creatorcontrib>Poindexter, Brenda B.</creatorcontrib><title>Retrospective review of neurodevelopmental outcomes in infants treated for neonatal abstinence syndrome</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective:
Little is known about developmental outcomes in neonatal abstinence syndrome (NAS). We hypothesized that children treated for NAS would score lower than the normative sample on the Bayley Scales of Infant Development, 3rd edition.
Study design:
We performed a retrospective cohort study of 87 infants treated for NAS and evaluated at 2 years of age.
Results:
Children treated for NAS scored significantly lower than the norm (mean 100) on all 3 subscales (cognitive mean 96.5, language mean 93.8, motor mean 94.0, all
p
< 0.03). Children who lived with foster/adoptive families at follow up had higher cognitive scores (median 100 vs. 95,
p
= 0.03) than those who lived with biological relatives, and were less likely to have motor scores <85 (
p
= 0.02). Eight percent of children required treatment for strabismus.
Conclusions:
Children treated for NAS are at risk for lower developmental scores and higher rates of strabismus at age 2 than the general population.</description><subject>692/308/409</subject><subject>692/700/1720</subject><subject>Adoptive families</subject><subject>Analysis</subject><subject>Babies</subject><subject>Birth weight</subject><subject>Child Development</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Developmental Disabilities - etiology</subject><subject>Disabled Children - statistics & numerical data</subject><subject>Diseases</subject><subject>Drug withdrawal</subject><subject>Feces</subject><subject>Female</subject><subject>Foster care</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants</subject><subject>Infants (Newborn)</subject><subject>Language Development</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morphine</subject><subject>Mothers</subject><subject>Motor Skills</subject><subject>Narcotics</subject><subject>Neonatal abstinence syndrome</subject><subject>Neonatal Abstinence Syndrome - complications</subject><subject>Neonatal Abstinence Syndrome - therapy</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Ohio</subject><subject>Pediatric research</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Primary care</subject><subject>Retrospective Studies</subject><subject>Strabismus</subject><subject>Strabismus - etiology</subject><subject>Toxicology</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kl1rFDEUhoModq3-AG9kQPBuaj43yY1Qil9QEESvQyZzspsyk6xJZqX_3ixb2y4oCQRynvflnORF6DXBFwQz9b5wwiTtMVE9xkr1-glaES7XvRCcPUUrLDnrFePrM_SilBuMD0X5HJ1RLYigVKzQ5jvUnMoOXA176DLsA_zuku8iLDmNsIcp7WaI1U5dWqpLM5QuxLa9jbV0NYOtMHY-5SZJ0R5AO5QaIkQHXbmNY26il-iZt1OBV3fnOfr56eOPqy_99bfPX68ur3snNK89U1i25onXisPQWlROjIPiVHGtvRPEj4NWgImXUg10JKNeC8ksGwQM3FF2jj4cfXfLMMPoWufZTmaXw2zzrUk2mNNKDFuzSXsjtNaCqmbw9s4gp18LlGpu0pJj69lQLDheY8LYA7WxE5j2GKmZuTkUZy6FpEIzwnGjLv5BtTXCHFyK4EO7PxG8eyTYgp3qtqRpqSHFcgqSI-ja55UM_n5Cgs0hG-aYDdOyYQ7ZMLpp3jx-mnvF3zA0gB6B0kpxA_lh9P-7_gHxxMUV</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Merhar, Stephanie L.</creator><creator>McAllister, Jennifer M.</creator><creator>Wedig-Stevie, Kathryn E.</creator><creator>Klein, Amy C.</creator><creator>Meinzen-Derr, Jareen</creator><creator>Poindexter, Brenda B.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20180501</creationdate><title>Retrospective review of neurodevelopmental outcomes in infants treated for neonatal abstinence syndrome</title><author>Merhar, Stephanie L. ; McAllister, Jennifer M. ; Wedig-Stevie, Kathryn E. ; Klein, Amy C. ; Meinzen-Derr, Jareen ; Poindexter, Brenda B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-38075541f984eb5228c5db8428499fc51fdb98e01f778b2d1d96573a3b5eb4c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>692/308/409</topic><topic>692/700/1720</topic><topic>Adoptive families</topic><topic>Analysis</topic><topic>Babies</topic><topic>Birth weight</topic><topic>Child Development</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Developmental Disabilities - etiology</topic><topic>Disabled Children - statistics & numerical data</topic><topic>Diseases</topic><topic>Drug withdrawal</topic><topic>Feces</topic><topic>Female</topic><topic>Foster care</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infants</topic><topic>Infants (Newborn)</topic><topic>Language Development</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morphine</topic><topic>Mothers</topic><topic>Motor Skills</topic><topic>Narcotics</topic><topic>Neonatal abstinence syndrome</topic><topic>Neonatal Abstinence Syndrome - complications</topic><topic>Neonatal Abstinence Syndrome - therapy</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Ohio</topic><topic>Pediatric research</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Primary care</topic><topic>Retrospective Studies</topic><topic>Strabismus</topic><topic>Strabismus - etiology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merhar, Stephanie L.</creatorcontrib><creatorcontrib>McAllister, Jennifer M.</creatorcontrib><creatorcontrib>Wedig-Stevie, Kathryn E.</creatorcontrib><creatorcontrib>Klein, Amy C.</creatorcontrib><creatorcontrib>Meinzen-Derr, Jareen</creatorcontrib><creatorcontrib>Poindexter, Brenda B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merhar, Stephanie L.</au><au>McAllister, Jennifer M.</au><au>Wedig-Stevie, Kathryn E.</au><au>Klein, Amy C.</au><au>Meinzen-Derr, Jareen</au><au>Poindexter, Brenda B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrospective review of neurodevelopmental outcomes in infants treated for neonatal abstinence syndrome</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>38</volume><issue>5</issue><spage>587</spage><epage>592</epage><pages>587-592</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective:
Little is known about developmental outcomes in neonatal abstinence syndrome (NAS). We hypothesized that children treated for NAS would score lower than the normative sample on the Bayley Scales of Infant Development, 3rd edition.
Study design:
We performed a retrospective cohort study of 87 infants treated for NAS and evaluated at 2 years of age.
Results:
Children treated for NAS scored significantly lower than the norm (mean 100) on all 3 subscales (cognitive mean 96.5, language mean 93.8, motor mean 94.0, all
p
< 0.03). Children who lived with foster/adoptive families at follow up had higher cognitive scores (median 100 vs. 95,
p
= 0.03) than those who lived with biological relatives, and were less likely to have motor scores <85 (
p
= 0.02). Eight percent of children required treatment for strabismus.
Conclusions:
Children treated for NAS are at risk for lower developmental scores and higher rates of strabismus at age 2 than the general population.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>29515225</pmid><doi>10.1038/s41372-018-0088-9</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of perinatology, 2018-05, Vol.38 (5), p.587-592 |
| issn | 0743-8346 1476-5543 |
| language | eng |
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| source | Springer Link |
| subjects | 692/308/409 692/700/1720 Adoptive families Analysis Babies Birth weight Child Development Child, Preschool Children Children & youth Cognition Cognitive ability Developmental Disabilities - etiology Disabled Children - statistics & numerical data Diseases Drug withdrawal Feces Female Foster care Gestational Age Humans Infant Infant, Newborn Infant, Premature Infants Infants (Newborn) Language Development Male Medicine Medicine & Public Health Morphine Mothers Motor Skills Narcotics Neonatal abstinence syndrome Neonatal Abstinence Syndrome - complications Neonatal Abstinence Syndrome - therapy Neonates Newborn babies Ohio Pediatric research Pediatric Surgery Pediatrics Primary care Retrospective Studies Strabismus Strabismus - etiology Toxicology |
| title | Retrospective review of neurodevelopmental outcomes in infants treated for neonatal abstinence syndrome |
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