Psoriasis risk in patients with diabetic retinopathy: A nationwide population-based study

Psoriasis is a chronic cutaneous disease known to be related with systemic disease; however, the association between psoriasis and diabetic complications has not been previously reported. Diabetic microvascular complications include diabetic retinopathy (DR), nephropathy, and neuropathy, and overt d...

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Bibliographic Details
Published in:Scientific reports 2018-06, Vol.8 (1), p.9086-7, Article 9086
Main Authors: Lee, Ji Hyun, Han, Ju Hee, Han, Kyung Do, Park, Young Min, Lee, Jun Young, Park, Yong-Gyu, Lee, Young Bok
Format: Article
Language:English
Subjects:
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692/699/2743/137/138
Diabetes
Diabetes mellitus
Diabetic nephropathy
Diabetic neuropathy
Diabetic retinopathy
Dialysis
End-stage renal disease
Humanities and Social Sciences
Kidney diseases
Kidney transplantation
Microvasculature
multidisciplinary
Nephropathy
Population studies
Population-based studies
Psoriasis
Renal failure
Retinopathy
Science
Science (multidisciplinary)
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Summary:Psoriasis is a chronic cutaneous disease known to be related with systemic disease; however, the association between psoriasis and diabetic complications has not been previously reported. Diabetic microvascular complications include diabetic retinopathy (DR), nephropathy, and neuropathy, and overt diabetic nephropathy can lead to the end-stage renal disease (ESRD).The present study investigated the association between psoriasis and non-proliferative DR (NPDR) or proliferative DR (PDR) or ESRD. We analyzed the relationship between diabetic complication and psoriasis using data from the National Health Insurance Service between 2009 and 2015. During a mean follow-up of 5.18 years, 43,792 patients were newly diagnosed with psoriasis. In Cox proportional hazard models, patients with NPDR (hazard ratio [HR] 1.26) had a higher incidence of psoriasis and patients with PDR patients had a higher risk of psoriasis (HR 1.35). ESRD was defined by the ICD-10 code, including chronic kidney disease/renal failure, transplantation, and dialysis. The incidence of psoriasis increased in DR patients with ESRD (HR 2.99, 95% CI 2.49–3.59, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-27147-0