Comparison of Two Protocols of Carbon Tetrachloride-Induced Cirrhosis in Rats – Improving Yield and Reproducibility

Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models of cirrhosis induced by orogastric administration of CCl4 once (CCl4-1xWk) or twice a week (CCl4-2xWk) for 12 week...

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Bibliographic Details
Published in:Scientific reports 2018-06, Vol.8 (1), p.9163-10, Article 9163
Main Authors: Fortea, José I, Fernández-Mena, Carolina, Puerto, Marta, Ripoll, Cristina, Almagro, Jorge, Bañares, Juan, Bellón, José M., Bañares, Rafael, Vaquero, Javier
Format: Article
Language:English
Subjects:
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Ascites
Atrophy
Body weight
Body weight gain
Carbon tetrachloride
Cirrhosis
Fibrosis
Gases
Hemodynamics
Humanities and Social Sciences
Hypertension
Liver
Liver cirrhosis
multidisciplinary
Renal function
Reproducibility
Rodents
Science
Science (multidisciplinary)
Splenomegaly
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Summary:Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models of cirrhosis induced by orogastric administration of CCl4 once (CCl4-1xWk) or twice a week (CCl4-2xWk) for 12 weeks in male Sprague-Dawley rats. Control rats received water instead of CCl4. Both CCl4 protocols similarly attenuated body weight gain (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-27427-9