Medication type modifies inflammatory response to traffic exposure in a population with type 2 diabetes

The association between residential traffic exposure and change in C-reactive protein over 2-years was evaluated using multivariate linear regression including interaction models for traffic and diabetes medication use/type (insulin vs. oral hypoglycemic agents (OHAs)). The study population was Puer...

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Bibliographic Details
Published in:Environmental pollution (1987) 2015-07, Vol.202, p.58-65
Main Authors: Rioux, Christine L., Tucker, Katherine L., Brugge, Doug, Mwamburi, Mkaya
Format: Article
Language:English
Subjects:
Adult
Air Pollutants - analysis
Air Pollutants - toxicity
Boston - epidemiology
C-reactive protein
C-Reactive Protein - metabolism
Density
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - epidemiology
Environmental Monitoring
Exposure
Female
Hispanic Americans
Housing
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - therapeutic use
Inflammation
Insulin
Insulin - administration & dosage
Insulin - therapeutic use
Linear Models
Male
Puerto Rican
Regression
Residential traffic exposure
Roadways
Traffic density
Traffic engineering
Traffic flow
Traffic proximity
Type 2 diabetes
Vehicle Emissions - analysis
Vehicle Emissions - toxicity
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Summary:The association between residential traffic exposure and change in C-reactive protein over 2-years was evaluated using multivariate linear regression including interaction models for traffic and diabetes medication use/type (insulin vs. oral hypoglycemic agents (OHAs)). The study population was Puerto Rican adults (n = 356) residing in greater Boston with type 2 diabetes. Traffic was characterized as proximity to roads with >20,000 weekday traffic volumes, and multi-directional traffic density. Increases in CRP concentration were significantly associated with residence ≤100 m of a roadway (p = 0.009) or near multiple roadways (p 
ISSN:0269-7491
1873-6424
DOI:10.1016/j.envpol.2015.03.012