Fibrin turnover and pleural organization: bench to bedside

Recent studies have shed new light on the role of the fibrinolytic system in the pathogenesis of pleural organization, including the mechanisms by which the system regulates mesenchymal transition of mesothelial cells and how that process affects outcomes of pleural injury. The key contribution of p...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2018-05, Vol.314 (5), p.L757-L768
Main Authors: Komissarov, Andrey A, Rahman, Najib, Lee, Y C Gary, Florova, Galina, Shetty, Sreerama, Idell, Richard, Ikebe, Mitsuo, Das, Kumuda, Tucker, Torry A, Idell, Steven
Format: Article
Language:English
Subjects:
Animals
Fibrin - metabolism
Humans
Pleural Diseases - metabolism
Pleural Diseases - physiopathology
Review
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Summary:Recent studies have shed new light on the role of the fibrinolytic system in the pathogenesis of pleural organization, including the mechanisms by which the system regulates mesenchymal transition of mesothelial cells and how that process affects outcomes of pleural injury. The key contribution of plasminogen activator inhibitor-1 to the outcomes of pleural injury is now better understood as is its role in the regulation of intrapleural fibrinolytic therapy. In addition, the mechanisms by which fibrinolysins are processed after intrapleural administration have now been elucidated, informing new candidate diagnostics and therapeutics for pleural loculation and failed drainage. The emergence of new potential interventional targets offers the potential for the development of new and more effective therapeutic candidates.
ISSN:1040-0605
1522-1504
DOI:10.1152/AJPLUNG.00501.2017