Association of ATM and BMI‐1 genetic variation with breast cancer risk in Han Chinese

We tested the hypothesis that genetic variation in ATM and BMI‐1 genes can alter the risk of breast cancer through genotyping 6 variants among 524 breast cancer cases and 518 cancer‐free controls of Han nationality. This was an observational, hospital‐based, case–control association study. Analyses...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2018-07, Vol.22 (7), p.3671-3678
Main Authors: Yue, Li‐Ling, Wang, Fu‐Chao, Zhang, Ming‐Long, Liu, Dan, Chen, Ping, Mei, Qing‐Bu, Li, Peng‐Hui, Pan, Hong‐Ming, Zheng, Li‐Hong
Format: Article
Language:English
Subjects:
Adolescent
Asian Continental Ancestry Group - genetics
association
Ataxia telangiectasia mutated protein
Ataxia Telangiectasia Mutated Proteins - genetics
ATM gene
BMI‐1 gene
Body mass
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Case-Control Studies
case–control
Female
Gene Frequency
Genetic diversity
Genetic Linkage
Genetic Predisposition to Disease
Genotyping
Haplotypes
Health risk assessment
Health risks
Humans
Menarche - genetics
Middle Aged
Nomograms
Original
Polycomb Repressive Complex 1 - genetics
Polymorphism, Single Nucleotide
risk
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Summary:We tested the hypothesis that genetic variation in ATM and BMI‐1 genes can alter the risk of breast cancer through genotyping 6 variants among 524 breast cancer cases and 518 cancer‐free controls of Han nationality. This was an observational, hospital‐based, case–control association study. Analyses of single variant, linkage, haplotype, interaction and nomogram were performed. Risk was expressed as odds ratio (OR) and 95% confidence interval (CI). All studied variants were in the Hardy‐Weinberg equilibrium and were not linked. The mutant allele frequencies of rs1890637, rs3092856 and rs1801516 in ATM gene were significantly higher in cases than in controls (P = .005,
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.13650