Association of TNF-α-308 G > A and −238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis

AbstractObjectiveA comprehensive search on electronic databases was conducted to identify all eligible studies of TNF-α polymorphisms and knee osteoarthritis (OA).MethodsEight studies on TNF-α -308 G > A and three on TNF-α -238G > A polymorphism were identified.ResultsOverall, the pooled ORs i...

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Bibliographic Details
Published in:Journal of orthopaedics 2018-09, Vol.15 (3), p.747-753
Main Authors: Sobhan, Mohammad Reza, Mahdinezhad-Yazdi, Masoud, Aghili, Kazem, Zare-Shehneh, Masoud, Rastegar, Shohreh, Sadeghizadeh-Yazdi, Jalal, Neamatzadeh, Hossein
Format: Article
Language:English
Subjects:
Knee
Meta-analysis
Orthopedics
Osteoarthritis
Polymorphism
Tumor necrosis factor-alpha
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Summary:AbstractObjectiveA comprehensive search on electronic databases was conducted to identify all eligible studies of TNF-α polymorphisms and knee osteoarthritis (OA).MethodsEight studies on TNF-α -308 G > A and three on TNF-α -238G > A polymorphism were identified.ResultsOverall, the pooled ORs indicated that neither TNF-α -238G > A nor -238G > A polymorphism was associated with knee OA risk. Similarly, in the stratified analysis by ethnicity, no significant association was found.ConclusionThis meta-analysis results inconsistent with the previous meta-analyses showed that the TNF-α -308 G > A and −238G > A polymorphisms may not be associated with the susceptibility to knee OA.
ISSN:0972-978X
0972-978X
DOI:10.1016/j.jor.2018.05.047