Probiotics improve insulin resistance status in an experimental model of Alzheimer's disease

• Published in: Medical journal of the Islamic Republic of Iran 2017, Vol.31 (1), p.103-704
• Main Authors: Athari Nik Azm, Somayeh, Djazayeri, Abolghassem, Safa, Majid, Azami, Kian, Djalali, Mahmoud, Sharifzadeh, Mohammad, Vafa, Mohammadreza
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 1016-1430; 2251-6840
• DOI: 10.14196/MJIRI.31.103

Nowadays, Alzheimer's disease (AD) is considered as Type 3 diabetes in which insulin resistance is the common cause of both diseases. Disruption of insulin signaling cascade and insulin resistance can induce AD; and central insulin resistance causes systemic alterations in serum insulin, FBS levels, and lipid profile. Studies have shown that probiotics ( and species) can be used as a nutritional approach to improve these metabolic changes. We assessed the probiotic effect (4 species of and ) on insulin resistance biomarkers in an experimental model of AD. A total of 60 rats were divided into 5 groups: (1) a control group without surgical and dietary intervention; (2) a controlprobiotics group receiving probiotics for 8 weeks, but not receiving any surgical intervention; (3) a group receiving a sham operation in which PBS was injected intrahippocampus but without dietary intervention; (4) an Alzheimer group for which Amyloid-ß (Aß) 1- 42 was injected intrahippocampus but without dietary intervention; (5) and an Alzheimer-probiotics group for which Aß1-42 was injected intrahippocampus and given 2g probiotics for 8 weeks. The FBS levels and lipid profile were measured by a calorimetric method, insulin levels were detected by an ELISA kit, and HOMA-IR was calculated using a formula. ANOVA (one way analysis of variance followed by Bonferroni comparisons post hoc) was used to compare all the variables between groups. Serum glucose, insulin levels, and HOMA-IR index increased in the Alzheimer group compared to the control (p