Opposing Actions of Developmental Trichloroethylene and High-Fat Diet Coexposure on Markers of Lipogenesis and Inflammation in Autoimmune-Prone Mice

Abstract Trichloroethylene (TCE) is a widespread environmental pollutant associated with immunotoxicity and autoimmune disease. Previous studies showed that mice exposed from gestation through early life demonstrated CD4+ T cell alterations and autoimmune hepatitis. Determining the role of one envir...

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Bibliographic Details
Published in:Toxicological sciences 2018-07, Vol.164 (1), p.313-327
Main Authors: Blossom, Sarah J, Fernandes, Lorenzo, Bai, Shasha, Khare, Sangeeta, Gokulan, Kuppan, Yuan, Youzhong, Dewall, Michael, Simmen, Frank A, Gilbert, Kathleen M
Format: Article
Language:English
Subjects:
Animals
Biomarkers - analysis
Cytokines - metabolism
Developmental Tce Exposure and High-Fat Diet
Diet, High-Fat - adverse effects
Environmental Pollutants - toxicity
Female
Hepatitis, Autoimmune - etiology
Hepatitis, Autoimmune - metabolism
Inflammation
Lipogenesis - drug effects
Maternal Exposure
Mice, Inbred MRL lpr
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
Prenatal Exposure Delayed Effects - etiology
Prenatal Exposure Delayed Effects - immunology
Trichloroethylene - toxicity
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Summary:Abstract Trichloroethylene (TCE) is a widespread environmental pollutant associated with immunotoxicity and autoimmune disease. Previous studies showed that mice exposed from gestation through early life demonstrated CD4+ T cell alterations and autoimmune hepatitis. Determining the role of one environmental risk factor for any disease is complicated by the presence of other stressors. Based on its known effects, we hypothesized that developmental overnutrition in the form of a moderately high-fat diet (HFD) consisting of 40% kcal fat would exacerbate the immunotoxicity and autoimmune-promoting effects of low-level (
ISSN:1096-6080
1096-0929
DOI:10.1093/toxsci/kfy091