Incidence and predictors of tenofovir disoproxil fumarate-induced renal impairment in HIV infected Nigerian patients

The use of tenofovir disoproxil fumarate (TDF) in the treatment of HIV infection has been associated with renal dysfunction. In Nigeria, data on the incidence and risk factors of TDF nephrotoxicity is sparse. We determined the cumulative incidence of and risk factors for TDF-induced renal impairment...

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Bibliographic Details
Published in:Germs (Bucureşti) 2018-06, Vol.8 (2), p.67-76
Main Authors: Ojeh, Bazim V, Abah, Isaac O, Ugoagwu, Placid, Agaba, Patricia A, Agbaji, Oche O, Gyang, Steven S
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antiretroviral drugs
Clinical medicine
Comorbidity
Complications and side effects
Diabetes
Dosage and administration
Drug therapy
Health aspects
Hepatitis
HIV
HIV patients
Human immunodeficiency virus
Hypertension
Kidney diseases
Kidney failure
Multivariate analysis
Original
Patients
Risk factors
Systematic review
Teaching hospitals
Tenofovir
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Summary:The use of tenofovir disoproxil fumarate (TDF) in the treatment of HIV infection has been associated with renal dysfunction. In Nigeria, data on the incidence and risk factors of TDF nephrotoxicity is sparse. We determined the cumulative incidence of and risk factors for TDF-induced renal impairment in HIV-infected individuals accessing care at the antiretroviral therapy (ART) clinic of Jos University Teaching Hospital, Nigeria. This retrospective cohort analysis included patients aged ≥16 years that initiated ART between January 2008 and December 2011. Renal impairment, defined as glomerular filtration rate GFR
ISSN:2248-2997
2248-2997
DOI:10.18683/germs.2018.1133