Incidence and predictors of tenofovir disoproxil fumarate-induced renal impairment in HIV infected Nigerian patients

The use of tenofovir disoproxil fumarate (TDF) in the treatment of HIV infection has been associated with renal dysfunction. In Nigeria, data on the incidence and risk factors of TDF nephrotoxicity is sparse. We determined the cumulative incidence of and risk factors for TDF-induced renal impairment...

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Published in:Germs (Bucureşti) 2018-06, Vol.8 (2), p.67-76
Main Authors: Ojeh, Bazim V, Abah, Isaac O, Ugoagwu, Placid, Agaba, Patricia A, Agbaji, Oche O, Gyang, Steven S
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antiretroviral drugs
Clinical medicine
Comorbidity
Complications and side effects
Diabetes
Dosage and administration
Drug therapy
Health aspects
Hepatitis
HIV
HIV patients
Human immunodeficiency virus
Hypertension
Kidney diseases
Kidney failure
Multivariate analysis
Original
Patients
Risk factors
Systematic review
Teaching hospitals
Tenofovir
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container_title Germs (Bucureşti)
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creator Ojeh, Bazim V
Abah, Isaac O
Ugoagwu, Placid
Agaba, Patricia A
Agbaji, Oche O
Gyang, Steven S
description The use of tenofovir disoproxil fumarate (TDF) in the treatment of HIV infection has been associated with renal dysfunction. In Nigeria, data on the incidence and risk factors of TDF nephrotoxicity is sparse. We determined the cumulative incidence of and risk factors for TDF-induced renal impairment in HIV-infected individuals accessing care at the antiretroviral therapy (ART) clinic of Jos University Teaching Hospital, Nigeria. This retrospective cohort analysis included patients aged ≥16 years that initiated ART between January 2008 and December 2011. Renal impairment, defined as glomerular filtration rate GFR
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In Nigeria, data on the incidence and risk factors of TDF nephrotoxicity is sparse. We determined the cumulative incidence of and risk factors for TDF-induced renal impairment in HIV-infected individuals accessing care at the antiretroviral therapy (ART) clinic of Jos University Teaching Hospital, Nigeria. This retrospective cohort analysis included patients aged ≥16 years that initiated ART between January 2008 and December 2011. Renal impairment, defined as glomerular filtration rate GFR <60 mL/min/1.73 sqm using the Modification of Diet in Renal Disease (MDRD) equation was assessed at baseline and at 48 weeks on ART. Logistic regression was performed to determine factors associated with incident renal impairment. The mean age was 39±9 years, and 67.1% were female. The cumulative incidence of renal impairment among the TDF-exposed and TDF-unexposed groups was 4.6% and 2.3% respectively (p<0.001). TDF exposure was significantly associated with renal impairment [OR=2.0, 95%CI=(1.48-2.89), p<0.001] in bivariate analysis. In multivariate analysis, older age (aOR=1.06, 95%CI=(1.05-1.08), p<0.001), TDF exposure [aOR=1.85, 95%CI=(1.31-2.60), p<0.001] and co-morbidities [aOR=2.71, 95%CI=(1.72-4.25), p<0.001] were significantly associated with renal impairment. TDF exposure, aging and comorbidities were predictors of renal toxicity among HIV positive patients. Regular monitoring of renal function in such high-risk individuals is recommended.]]></description><identifier>ISSN: 2248-2997</identifier><identifier>EISSN: 2248-2997</identifier><identifier>DOI: 10.18683/germs.2018.1133</identifier><identifier>PMID: 29951379</identifier><language>eng</language><publisher>Romania: Asociatia pentru Cresterea Vizibilitatii Cercetarii Stiintifice (ACVCS)</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Antiretroviral drugs ; Clinical medicine ; Comorbidity ; Complications and side effects ; Diabetes ; Dosage and administration ; Drug therapy ; Health aspects ; Hepatitis ; HIV ; HIV patients ; Human immunodeficiency virus ; Hypertension ; Kidney diseases ; Kidney failure ; Multivariate analysis ; Original ; Patients ; Risk factors ; Systematic review ; Teaching hospitals ; Tenofovir</subject><ispartof>Germs (Bucureşti), 2018-06, Vol.8 (2), p.67-76</ispartof><rights>COPYRIGHT 2018 Asociatia pentru Cresterea Vizibilitatii Cercetarii Stiintifice (ACVCS)</rights><rights>Copyright European HIV/AIDS and Infectious Diseases Academy Jun 2018</rights><rights>GERMS 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-5b10a0eb4fe597e7116b139f56f1827eea83ec13508d8ba1878e5c8c5b6946cc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2117322670/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2117322670?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29951379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ojeh, Bazim V</creatorcontrib><creatorcontrib>Abah, Isaac O</creatorcontrib><creatorcontrib>Ugoagwu, Placid</creatorcontrib><creatorcontrib>Agaba, Patricia A</creatorcontrib><creatorcontrib>Agbaji, Oche O</creatorcontrib><creatorcontrib>Gyang, Steven S</creatorcontrib><title>Incidence and predictors of tenofovir disoproxil fumarate-induced renal impairment in HIV infected Nigerian patients</title><title>Germs (Bucureşti)</title><addtitle>Germs</addtitle><description><![CDATA[The use of tenofovir disoproxil fumarate (TDF) in the treatment of HIV infection has been associated with renal dysfunction. In Nigeria, data on the incidence and risk factors of TDF nephrotoxicity is sparse. We determined the cumulative incidence of and risk factors for TDF-induced renal impairment in HIV-infected individuals accessing care at the antiretroviral therapy (ART) clinic of Jos University Teaching Hospital, Nigeria. This retrospective cohort analysis included patients aged ≥16 years that initiated ART between January 2008 and December 2011. Renal impairment, defined as glomerular filtration rate GFR <60 mL/min/1.73 sqm using the Modification of Diet in Renal Disease (MDRD) equation was assessed at baseline and at 48 weeks on ART. Logistic regression was performed to determine factors associated with incident renal impairment. The mean age was 39±9 years, and 67.1% were female. The cumulative incidence of renal impairment among the TDF-exposed and TDF-unexposed groups was 4.6% and 2.3% respectively (p<0.001). TDF exposure was significantly associated with renal impairment [OR=2.0, 95%CI=(1.48-2.89), p<0.001] in bivariate analysis. In multivariate analysis, older age (aOR=1.06, 95%CI=(1.05-1.08), p<0.001), TDF exposure [aOR=1.85, 95%CI=(1.31-2.60), p<0.001] and co-morbidities [aOR=2.71, 95%CI=(1.72-4.25), p<0.001] were significantly associated with renal impairment. TDF exposure, aging and comorbidities were predictors of renal toxicity among HIV positive patients. 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TDF exposure was significantly associated with renal impairment [OR=2.0, 95%CI=(1.48-2.89), p<0.001] in bivariate analysis. In multivariate analysis, older age (aOR=1.06, 95%CI=(1.05-1.08), p<0.001), TDF exposure [aOR=1.85, 95%CI=(1.31-2.60), p<0.001] and co-morbidities [aOR=2.71, 95%CI=(1.72-4.25), p<0.001] were significantly associated with renal impairment. TDF exposure, aging and comorbidities were predictors of renal toxicity among HIV positive patients. Regular monitoring of renal function in such high-risk individuals is recommended.]]></abstract><cop>Romania</cop><pub>Asociatia pentru Cresterea Vizibilitatii Cercetarii Stiintifice (ACVCS)</pub><pmid>29951379</pmid><doi>10.18683/germs.2018.1133</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Acquired immune deficiency syndrome
AIDS
Antiretroviral drugs
Clinical medicine
Comorbidity
Complications and side effects
Diabetes
Dosage and administration
Drug therapy
Health aspects
Hepatitis
HIV
HIV patients
Human immunodeficiency virus
Hypertension
Kidney diseases
Kidney failure
Multivariate analysis
Original
Patients
Risk factors
Systematic review
Teaching hospitals
Tenofovir
title Incidence and predictors of tenofovir disoproxil fumarate-induced renal impairment in HIV infected Nigerian patients
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