Elevated serum levels of bone sialoprotein during ICU treatment predict long-term mortality in critically ill patients

Bone sialoprotein (BSP), a member of the SIBLINGs (for Small Integrin-Binding LIgand, N-linked Glycoproteins) family, has recently be associated to inflammatory and infectious diseases. We therefore measured BSP concentrations in 136 patients at admission to the intensive care unit (ICU) and 3 days...

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Published in:Scientific reports 2018-06, Vol.8 (1), p.9750-10, Article 9750
Main Authors: Luedde, Mark, Roy, Sanchari, Hippe, Hans-Joerg, Cardenas, David Vargas, Spehlmann, Martina, Vucur, Mihael, Hoening, Pia, Loosen, Sven, Frey, Norbert, Trautwein, Christian, Luedde, Tom, Koch, Alexander, Tacke, Frank, Roderburg, Christoph
Format: Article
Language:English
Subjects:
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Blood donors
Bone sialoprotein
Data processing
Glycoproteins
Humanities and Social Sciences
Infectious diseases
Intensive care
Mortality
multidisciplinary
Patients
Science
Science (multidisciplinary)
Serum levels
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Summary:Bone sialoprotein (BSP), a member of the SIBLINGs (for Small Integrin-Binding LIgand, N-linked Glycoproteins) family, has recently be associated to inflammatory and infectious diseases. We therefore measured BSP concentrations in 136 patients at admission to the intensive care unit (ICU) and 3 days of ICU. BSP levels were compared to 36 healthy blood donors and correlated to clinical data. In these analysis, BSP serum levels were strongly elevated at the time point of admission to the ICU when compared to healthy controls. Moreover BSP concentrations were significantly elevated after 3 days of treatment on the intensive care unit. A further increase in BSP levels was detected in patients with higher APACHE-II-scores and in patients with septic disease. While in most patients, BSP levels decreased during the first three days of treatment on a medical ICU, patients with persistently elevated BSP levels displayed an unfavorable outcome. In these patients, persistently elevated BSP concentrations were a superior predictor of mortality than established indicators of patient´ prognosis such as the SAPS2 or the APACHE-II score. In summary, our data argue for a novel utility for BSP as a biomarker in patients treated on a medical ICU.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-28201-7