Creation of monosodium iodoacetate-induced model of osteoarthritis in rabbit knee joint

According to the OARSI OA cartilage histopathological system, the control knee without MIA [Figure A]1 and [Figure A]2, 2.5 mg of MIA/250 μl and 3 mg of MIA/50 μl showed no change. The commonly described animal model of OA involves transection of anterior cruciate ligament in the knee joint (mechani...

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Bibliographic Details
Published in:Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2018-03, Vol.147 (3), p.312-314
Main Authors: Vinod, Elizabeth, Boopalan, P. R. J. V. C., Arumugam, Sabareeswaran, Sathishkumar, Solomon
Format: Article
Language:English
Subjects:
Acetates
Animals
Arthritis
Biomarkers
Correspondence
Disease
Disease Models, Animal
Health aspects
Histopathology
Injections, Intra-Articular
Iodoacetates
Knee
Knee Joint
Ligaments
Osteoarthritis
Physiological aspects
Pilot Projects
Proteins
Rabbits
Rats
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Summary:According to the OARSI OA cartilage histopathological system, the control knee without MIA [Figure A]1 and [Figure A]2, 2.5 mg of MIA/250 μl and 3 mg of MIA/50 μl showed no change. The commonly described animal model of OA involves transection of anterior cruciate ligament in the knee joint (mechanical model) and the ensuing mechanical instability results in cartilage damage [2],[3]. [...]intra-articular injection of MIA into rabbit knee joints can be used to create an experimental model of OA.
ISSN:0971-5916
DOI:10.4103/ijmr.IJMR_2004_16