Systemic Inflammatory Response Syndrome (SIRS) and the Pattern and Risk of Sepsis Following Gastrointestinal Perforation

BACKGROUND Systemic inflammatory response syndrome (SIRS) is characterized by systemic inflammation and tissue injury. Secondary sepsis is a common critical illness associated with poor clinical outcome. The aim of this study was to investigate the risk of SIRS-positive and SIRS-negative sepsis foll...

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Bibliographic Details
Published in:Medical science monitor 2018-06, Vol.24, p.3888-3894
Main Authors: Ye-Ting, Zhou, Dao-Ming, Tong
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Clinical Research
Female
Humans
Intestinal Perforation - complications
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Risk Factors
Sepsis - epidemiology
Sepsis - etiology
Systemic Inflammatory Response Syndrome - etiology
Young Adult
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Summary:BACKGROUND Systemic inflammatory response syndrome (SIRS) is characterized by systemic inflammation and tissue injury. Secondary sepsis is a common critical illness associated with poor clinical outcome. The aim of this study was to investigate the risk of SIRS-positive and SIRS-negative sepsis following gastrointestinal (GI) perforation. MATERIAL AND METHODS A retrospective study included 51 patients with GI perforation who had clinical evidence of sepsis, with or without SIRS. Clinical outcome was assessed at day 30 using the Glasgow Outcome Scale (GOS) (score, 1-5) and the sequential organ failure assessment (SOFA) (score, 1-6) to determine organ function. RESULTS Fifty-one patients were included in the study (median age, 74 years; 37 male patients); 20 patients (39.2%) developed secondary sepsis; 16 patients (80%) had SIRS-negative sepsis; four patients had SIRS-positive sepsis. An increased SOFA score was a significant independent predictor of GI perforation with sepsis (5.4±3.1 vs. 1.5±2.8) (P
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.907922