Lateral Hypothalamic Stimulation Reduces Hyperalgesia Through Spinally Descending Orexin-A Neurons in Neuropathic Pain

No evidence to date shows that lateral hypothalamic (LH) stimulation produces orexin-A-mediated antinociception in the spinal cord dorsal horn (SCDH) in a model of neuropathic pain. We conducted experiments to examine the effect of orexin-A-mediated LH stimulation in female rats with chronic constri...

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Bibliographic Details
Published in:Western journal of nursing research 2016-03, Vol.38 (3), p.292-307
Main Authors: Wardach, Jacob, Wagner, Monica, Jeong, Younhee, Holden, Janean E.
Format: Article
Language:English
Subjects:
Analgesics, Non-Narcotic - pharmacology
Animals
Benzoxazoles - pharmacology
Brain
Carbachol - pharmacology
Chronic pain
Female
Hostility
Hyperalgesia
Hyperalgesia - drug therapy
Hypothalamic Area, Lateral - physiopathology
Injuries
Nervous system
Neuralgia - drug therapy
Neurons
Neuropathology
Nursing
Orexins - antagonists & inhibitors
Pain
Pain Management
Random Allocation
Rats
Rats, Sprague-Dawley
Rodents
Spinal cord
Spinal Cord Dorsal Horn - physiopathology
Stimulation
Urea - analogs & derivatives
Urea - pharmacology
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Summary:No evidence to date shows that lateral hypothalamic (LH) stimulation produces orexin-A-mediated antinociception in the spinal cord dorsal horn (SCDH) in a model of neuropathic pain. We conducted experiments to examine the effect of orexin-A-mediated LH stimulation in female rats with chronic constriction injury (CCI) on thermal hyperalgesia. Rats receiving carbachol into the LH demonstrated antinociception on both the left CCI and right nonligated paws (p < .05). Rats were given carbachol in the LH followed by intrathecal injection of the orexin-1 (OX1) receptor antagonist SB-334867, which blocked LH-induced antinociception compared with control groups (p < .05) in the left paw, but not in the right paw. These findings support the hypothesis that LH stimulation produces antinociception in rats with thermal hyperalgesia from neuropathic pain via an orexin-A connection between the LH and the SCDH. Identification of this pathway may lead to studies using orexins to manage clinical pain.
ISSN:0193-9459
1552-8456
DOI:10.1177/0193945915610083