Overview of the Cytoskeleton from an Evolutionary Perspective

Organisms in the three domains of life depend on protein polymers to form a cytoskeleton that helps to establish their shapes, maintain their mechanical integrity, divide, and, in many cases, move. Eukaryotes have the most complex cytoskeletons, comprising three cytoskeletal polymers-actin filaments...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2018-07, Vol.10 (7), p.a030288
Main Authors: Pollard, Thomas D, Goldman, Robert D
Format: Article
Language:English
Subjects:
Actin
CONCEPTS
Cytoskeleton
Dynein
Eukaryotes
Filaments
Homology
Intermediate filaments
Kinesin
Microtubules
Molecular motors
Myosin
Polymers
Prokaryotes
Proteins
Tubulin
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Summary:Organisms in the three domains of life depend on protein polymers to form a cytoskeleton that helps to establish their shapes, maintain their mechanical integrity, divide, and, in many cases, move. Eukaryotes have the most complex cytoskeletons, comprising three cytoskeletal polymers-actin filaments, intermediate filaments, and microtubules-acted on by three families of motor proteins (myosin, kinesin, and dynein). Prokaryotes have polymers of proteins homologous to actin and tubulin but no motors, and a few bacteria have a protein related to intermediate filament proteins.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a030288