Interleukin 15 concentrations in follicular fluid and their effect on oocyte maturation in subfertile women undergoing intracytoplasmic sperm injection

Purpose To calculate the concentrations of interleukin 15 (IL-15) in follicular fluid (FF) and evaluate their relation with oocyte maturation, follicle size, and patients’ body mass index (BMI) and age. Methods Follicular fluid specimens were obtained from 56 subfertile women undergoing intracytopla...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2018-06, Vol.35 (6), p.1019-1025
Main Authors: Spanou, S., Kalogiannis, D., Zapanti, E., Gazouli, M., Sfontouris, I. A., Siristatidis, C., Mastorakos, George
Format: Article
Language:English
Subjects:
Adult
Age
Body mass index
Body size
Cohort Studies
Cross-Sectional Studies
Cytokines
Enzyme-linked immunosorbent assay
Female
Fertility
Follicles
Follicular fluid
Follicular Fluid - metabolism
Gynecology
Human Genetics
Humans
In Vitro Oocyte Maturation Techniques
Infertility, Female - physiopathology
Injection
Interleukin 15
Interleukin-15 - metabolism
Maturation
Medicine
Medicine & Public Health
Middle Aged
Oocytes
Oogenesis
Ovulation Induction
Pregnancy
Pregnancy Outcome
Reproductive Medicine
Reproductive Physiology and Disease
Sperm
Sperm Injections, Intracytoplasmic
Young Adult
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Summary:Purpose To calculate the concentrations of interleukin 15 (IL-15) in follicular fluid (FF) and evaluate their relation with oocyte maturation, follicle size, and patients’ body mass index (BMI) and age. Methods Follicular fluid specimens were obtained from 56 subfertile women undergoing intracytoplasmic sperm injection (ICSI) during oocyte retrieval for measurement of IL-15 concentrations with ELISA. Wilcoxon’s test and Pearson’s correlation coefficient were used to correlate FF concentrations of IL-15 with follicular size and stage of oocyte maturation, along with patients’ BMI and age. Results IL-15 concentrations in FF of follicles with immature oocytes were significantly greater than those from follicles with mature ones (median 5.333 vs. 3.250 pg/ml, respectively, p   0.05). Conclusions IL-15 concentrations in FF are adversely related with the size of the follicles and the maturity of the corresponding retrieved oocytes in a cohort of expected normal responders undergoing intracytoplasmic sperm injection (ICSI). Follicular fluid concentrations of IL-15 should be investigated as a possible predictive factor for oocyte maturity.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-018-1170-0