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Intermittent resistance exercise and obesity, considered separately or combined, impair spermatic parameters in adult male Wistar rats

Summary Obesity and absence of physical exercise are global problems that affect concentration and sperm quality in the male reproductive system. The purpose of this study was to examine the effect of obesity and resistance training, considered separately or in association, on testicular function an...

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Published in:International journal of experimental pathology 2018-04, Vol.99 (2), p.95-102
Main Authors: Punhagui, Ana Paula Franco, Teixeira, Giovana Rampazzo, Freitas, Marcelo Conrado, Seraphim, Patricia Monteiro, Fernandes, Glaura Scantamburlo Alves
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container_title International journal of experimental pathology
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description Summary Obesity and absence of physical exercise are global problems that affect concentration and sperm quality in the male reproductive system. The purpose of this study was to examine the effect of obesity and resistance training, considered separately or in association, on testicular function and reproductive capacity. Twenty pubertal male Wistar rats were distributed into four groups: control (C) and exercise (E) groups that received standard rat chow; and obese (O) and obese with exercise (OE) groups that received a high‐fat diet. All the groups received filtered water during the experimental conditions. Groups E and OE were submitted to 8 weeks of high‐intensity intermittent training. Afterwards, testes were collected for sperm count, spermatogenic kinetics, histopathology, morphometry and immunodetection of androgen receptors (AR). The vas deferens was collected for sperm morphology. The results showed that obesity increased body weight, naso‐anal length, liver and epididymal fat weight, abnormal spermatozoa and immunodetectable AR. Intermittent exercise decreased daily sperm production (DSP), sperm count and normal spermatozoa, whereas the number of tubules with immunodetectable AR increased. The combination of obesity and intermittent training led to reduced sperm count and DSP, although abnormal spermatozoa and the number of tubules with immunodetectable AR increased. Thus, in conclusion, both obesity and resistance training impaired testicular function during puberty in rats; and this type of exercise has also been shown to be detrimental to testicular physiology.
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The purpose of this study was to examine the effect of obesity and resistance training, considered separately or in association, on testicular function and reproductive capacity. Twenty pubertal male Wistar rats were distributed into four groups: control (C) and exercise (E) groups that received standard rat chow; and obese (O) and obese with exercise (OE) groups that received a high‐fat diet. All the groups received filtered water during the experimental conditions. Groups E and OE were submitted to 8 weeks of high‐intensity intermittent training. Afterwards, testes were collected for sperm count, spermatogenic kinetics, histopathology, morphometry and immunodetection of androgen receptors (AR). The vas deferens was collected for sperm morphology. The results showed that obesity increased body weight, naso‐anal length, liver and epididymal fat weight, abnormal spermatozoa and immunodetectable AR. Intermittent exercise decreased daily sperm production (DSP), sperm count and normal spermatozoa, whereas the number of tubules with immunodetectable AR increased. The combination of obesity and intermittent training led to reduced sperm count and DSP, although abnormal spermatozoa and the number of tubules with immunodetectable AR increased. 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The purpose of this study was to examine the effect of obesity and resistance training, considered separately or in association, on testicular function and reproductive capacity. Twenty pubertal male Wistar rats were distributed into four groups: control (C) and exercise (E) groups that received standard rat chow; and obese (O) and obese with exercise (OE) groups that received a high‐fat diet. All the groups received filtered water during the experimental conditions. Groups E and OE were submitted to 8 weeks of high‐intensity intermittent training. Afterwards, testes were collected for sperm count, spermatogenic kinetics, histopathology, morphometry and immunodetection of androgen receptors (AR). The vas deferens was collected for sperm morphology. The results showed that obesity increased body weight, naso‐anal length, liver and epididymal fat weight, abnormal spermatozoa and immunodetectable AR. Intermittent exercise decreased daily sperm production (DSP), sperm count and normal spermatozoa, whereas the number of tubules with immunodetectable AR increased. The combination of obesity and intermittent training led to reduced sperm count and DSP, although abnormal spermatozoa and the number of tubules with immunodetectable AR increased. 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The purpose of this study was to examine the effect of obesity and resistance training, considered separately or in association, on testicular function and reproductive capacity. Twenty pubertal male Wistar rats were distributed into four groups: control (C) and exercise (E) groups that received standard rat chow; and obese (O) and obese with exercise (OE) groups that received a high‐fat diet. All the groups received filtered water during the experimental conditions. Groups E and OE were submitted to 8 weeks of high‐intensity intermittent training. Afterwards, testes were collected for sperm count, spermatogenic kinetics, histopathology, morphometry and immunodetection of androgen receptors (AR). The vas deferens was collected for sperm morphology. The results showed that obesity increased body weight, naso‐anal length, liver and epididymal fat weight, abnormal spermatozoa and immunodetectable AR. Intermittent exercise decreased daily sperm production (DSP), sperm count and normal spermatozoa, whereas the number of tubules with immunodetectable AR increased. The combination of obesity and intermittent training led to reduced sperm count and DSP, although abnormal spermatozoa and the number of tubules with immunodetectable AR increased. Thus, in conclusion, both obesity and resistance training impaired testicular function during puberty in rats; and this type of exercise has also been shown to be detrimental to testicular physiology.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29781539</pmid><doi>10.1111/iep.12270</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6043-1131</orcidid><oa>free_for_read</oa></addata></record>
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subjects androgen receptor
Androgen receptors
Animals
Body weight
Disease Models, Animal
High fat diet
Histopathology
intermittent resistance exercise
Kinetics
Liver
Male
Morphology
Morphometry
Obesity
Obesity - complications
Obesity - metabolism
Obesity - pathology
Original
Physical exercise
Physical training
Puberty
Rats
Rats, Wistar
Receptors
Receptors, Androgen
Reproductive system
Resistance training
Resistance Training - adverse effects
Rodents
Sperm
Sperm Count
Spermatogenesis
Spermatozoa
Spermatozoa - pathology
Strength training
Testes
testis
Testis - metabolism
Testis - pathology
Training
Tubules
Vas deferens
Water purification
title Intermittent resistance exercise and obesity, considered separately or combined, impair spermatic parameters in adult male Wistar rats
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